Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Zhaofeng Zhang; Ming Zhao; Qiong Li; Haifeng Zhao; Junbo Wang; Yong Li

doi:10.1016/j.febslet.2008.12.053

Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Zhaofeng Zhang
, Ming Zhao
, Qiong Li
, Haifeng Zhao
, Junbo Wang
, Yong Li

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

Original language	English (US)
Pages (from-to)	470-474
Number of pages	5
Journal	FEBS Letters
Volume	583
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2008.12.053
State	Published - Jan 22 2009
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People’s Republic of China.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AMP-activated protein kinase
Acetyl-l-carnitine
Insulin resistance
Tumor necrosis factor-α

Publisher link

10.1016/j.febslet.2008.12.053

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title = "Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells",

abstract = "In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.",

keywords = "AMP-activated protein kinase, Acetyl-l-carnitine, Insulin resistance, Tumor necrosis factor-α",

author = "Zhaofeng Zhang and Ming Zhao and Qiong Li and Haifeng Zhao and Junbo Wang and Yong Li",

note = "Funding Information: This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People{\textquoteright}s Republic of China.",

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doi = "10.1016/j.febslet.2008.12.053",

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AU - Zhang, Zhaofeng

AU - Zhao, Ming

AU - Li, Qiong

AU - Zhao, Haifeng

AU - Wang, Junbo

AU - Li, Yong

N1 - Funding Information: This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People’s Republic of China.

PY - 2009/1/22

Y1 - 2009/1/22

N2 - In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

AB - In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

KW - AMP-activated protein kinase

KW - Acetyl-l-carnitine

KW - Insulin resistance

KW - Tumor necrosis factor-α

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DO - 10.1016/j.febslet.2008.12.053

M3 - Article

C2 - 19121314

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Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Abstract

Bibliographical note

UN SDGs

Keywords

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