Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Zhaofeng Zhang; Ming Zhao; Qiong Li; Haifeng Zhao; Junbo Wang; Yong Li

doi:10.1016/j.febslet.2008.12.053

Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Zhaofeng Zhang, Ming Zhao, Qiong Li, Haifeng Zhao, Junbo Wang, Yong Li

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

Original language	English (US)
Pages (from-to)	470-474
Number of pages	5
Journal	FEBS Letters
Volume	583
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2008.12.053
State	Published - Jan 22 2009
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People’s Republic of China.

Keywords

AMP-activated protein kinase
Acetyl-l-carnitine
Insulin resistance
Tumor necrosis factor-α

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2008.12.053

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title = "Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells",

abstract = "In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.",

keywords = "AMP-activated protein kinase, Acetyl-l-carnitine, Insulin resistance, Tumor necrosis factor-α",

author = "Zhaofeng Zhang and Ming Zhao and Qiong Li and Haifeng Zhao and Junbo Wang and Yong Li",

note = "Funding Information: This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People{\textquoteright}s Republic of China.",

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AU - Zhang, Zhaofeng

AU - Zhao, Ming

AU - Li, Qiong

AU - Zhao, Haifeng

AU - Wang, Junbo

AU - Li, Yong

N1 - Funding Information: This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People’s Republic of China.

PY - 2009/1/22

Y1 - 2009/1/22

N2 - In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

AB - In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

KW - AMP-activated protein kinase

KW - Acetyl-l-carnitine

KW - Insulin resistance

KW - Tumor necrosis factor-α

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Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Abstract

Bibliographical note

Keywords

UN SDGs

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