Acetyl-l-carnitine inhibits TNF-α-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

Zhaofeng Zhang, Ming Zhao, Qiong Li, Haifeng Zhao, Junbo Wang, Yong Li

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalFEBS Letters
Volume583
Issue number2
DOIs
StatePublished - Jan 22 2009

Bibliographical note

Funding Information:
This work was supported by the foundation (No. 2006BAD27B01) from the Ministry of Science and Technology of the People’s Republic of China.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • AMP-activated protein kinase
  • Acetyl-l-carnitine
  • Insulin resistance
  • Tumor necrosis factor-α

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