Accumulation of Mn(II) in Deinicoccus radiodurans facilitates gamma-radiation resistance

M. J. Daly, E. K. Gaidamakova, V. Y. Matrosova, A. Vasilenko, M. Zhai, A. Venkateswaran, M. Hess, M. V. Omelchenko, H. M. Kostandarithes, K. S. Makarova, Lawrence P Wackett, J. K. Fredrickson, D. Ghosal

Research output: Contribution to journalArticlepeer-review

519 Scopus citations

Abstract

Deinococcus radiodurans is extremely resistant to ionizing radiation. How this bacterium can grow under chronic γ radiation [50 grays (Gy) per hour] or recover from acute doses greater than 10 kCy is unknown. We show that D. radiodurans accumulates very high intracellular manganese and low iron levels compared with radiation-sensitive bacteria and that resistance exhibits a concentration-dependent response to manganous chloride [Mn(II)]. Among the most radiation-resistant bacterial groups reported, Deinococcus, Enterococcus, Lactobacillus, and cyanobacteria accumulate Mn(II). In contrast, Shewanella oneidensis and Pseudomonas putida have high iron but low intra-cellular manganese concentrations and are very sensitive. We propose that Mn(II) accumulation facilitates recovery from radiation injury.

Original languageEnglish (US)
Pages (from-to)1025-1028
Number of pages4
JournalScience
Volume306
Issue number5698
DOIs
StatePublished - Nov 5 2004

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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