Access to functionalized steroid side chains via modified Julia olefination

Enver Cagri Izgu, Aaron C. Burns, Thomas R. Hoye

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Various functionalized steroidal side chains were conveniently accessed by a modified Julia olefination strategy using a common sulfone donor and an appropriate α-branched aldehyde acceptor. For the coupling of these hindered classes of reaction partners (and in contrast to typically observed trends), the benzothiazolyl(BT)-sulfone anion gave superior outcomes compared to the phenyltetrazolyl(PT)-sulfone anion.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalOrganic Letters
Volume13
Issue number4
DOIs
StatePublished - Feb 18 2011

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