To inform HIV/STI prevention messaging, the authors used cross-sectional data from 1,231 men who have sex with men (MSM) to examine the acceptability of strategies for delivering prevention messages in sexually explicit media (SEM). The majority of participants (83%) found it acceptable to include prevention messages in SEM. A latent profile analysis identified three classifications of men with similar views on the acceptability of strategies. Compared to men endorsing some strategies (54%), men endorsing all strategies (29%) were younger (PORadj = 0.56 [0.39, 0.79]) and preferred viewing SEM in which the actors used condoms for anal sex (PORadj = 1.53 [1.05, 2.23]). Men endorsing no strategies (17%) were of similar age to men endorsing some, but were more likely to prefer viewing SEM in which the actors did not use condoms (PORadj = 2.44 [1.43, 4.16]) and to report engaging in insertive unprotected anal sex within the past 3 months (PORadj = 2.03 [1.11, 3.70]). Opportunities exist to use SEM for HIV/STI prevention.