Accelerated therapeutic progress in diffuse large B cell lymphoma

Qingqing Cai, Jason Westin, Kai Fu, Madhav Desai, Liang Zhang, Huiqiang Huang, Wenqi Jiang, Rong Liang, Zhengzi Qian, Richard E. Champlin, Michael Wang

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in the world. Clinically, biologically, and pathologically, DLBCL is a heterogeneous entity with a range of potential outcomes. Immunochemotherapy regimens, consisting of the chimeric monoclonal anti-CD20 antibody rituximab in combination with chemotherapy, have improved the outcomes. Relapsed DLBCL is generally treated with salvage immunochemotherapy followed by high-dose therapy and autologous stem cell transplantation; however, DLBCL is not yet curable in up to a third of patients. The real promise for cure lies in novel agents and their rational combinations. The improved understanding of DLBCL subtypes and gene expression profiling has led to the identification of targeted drugs that may allow for subtype specific therapy. We have summarized the existing data on the prognostic factors and the treatment of DLBCL, including the use of novel agents such as lenalidomide, carfilzomib, and ibrutinib. We also share our thoughts on the direction of future clinical trials.

Original languageEnglish (US)
Pages (from-to)541-556
Number of pages16
JournalAnnals of Hematology
Volume93
Issue number4
DOIs
StatePublished - Apr 2014
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments This manuscript has been approved by philanthropy funding for Edward E. Crutchfield and Thomas Hunter III. This work was supported by the China Scholarship Council, National Nature Science Foundation of China (81372883, 81001052), Science and Technology Planning Project of Guangdong Province, China (2011B031800222), Young Talents Project of Sun Yat-sen University Cancer Center (to Cai Qingqing), Young Talents Project of Sun Yat-sen University (to Cai Qingqing).

Keywords

  • Diffuse large B cell lymphoma
  • Immunochemotherapy
  • Novel biological agents
  • Rituximab

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