Accelerated kindling development in μ-opioid receptor deficient mice

G. Grecksch, A. Becker, H. Schroeder, J. Kraus, H. Loh, V. Höllt

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The relevance of μ-opioid systems for central excitability and kindling related disturbed learning performance was underlined by investigations using μ-opioid receptor knockout mice. Mice lacking μ-opioid receptors showed an accelerated kindling development induced by the convulsant drug pentylenetetrazol. Blockade of δ-opioid receptors by naltrindole suppressing kindling development in wild-type animals led to a further acceleration of kindled seizure development in the knockout mice. Mice lacking μ-opioid receptors showed such a low learning performance in the shuttle box, that the kindling induced learning deficit as seen in wild-type mice was not detected. The results were discussed on the basis of receptor binding studies with regard to subtypes of glutamatergic receptors, δ-opioid and somatostatin receptors. An increase in glutamate and so-matostatin binding could contribute to the enhanced excitability in the-μ-opioid receptor knockout mice.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume369
Issue number3
DOIs
StatePublished - Mar 1 2004

Keywords

  • Chemical kindling
  • Receptor binding
  • Shuttle box learning
  • Transgenic mice
  • μ-Opioid receptor

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