Accelerated contrast-enhanced whole-heart coronary MRI using low-dimensional-structure self-learning and thresholding

Mehmet Akçakaya, Tamer A. Basha, Raymond H. Chan, Hussein Rayatzadeh, Kraig V. Kissinger, Beth Goddu, Lois A. Goepfert, Warren J. Manning, Reza Nezafat

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We sought to evaluate the efficacy of prospective random undersampling and low-dimensional-structure self-learning and thresholding reconstruction for highly accelerated contrast-enhanced whole-heart coronary MRI. A prospective random undersampling scheme was implemented using phase ordering to minimize artifacts due to gradient switching and was compared to a randomly undersampled acquisition with no profile ordering. This profile-ordering technique was then used to acquire contrast-enhanced whole-heart coronary MRI in 10 healthy subjects with 4-fold acceleration. Reconstructed images and the acquired zero-filled images were compared for depicted vessel length, vessel sharpness, and subjective image quality on a scale of 1 (poor) to 4 (excellent). In a pilot study, contrast-enhanced whole-heart coronary MRI was also acquired in four patients with suspected coronary artery disease with 3-fold acceleration. The undersampled images were reconstructed using low-dimensional-structure self-learning and thresholding, which showed significant improvement over the zero-filled images in both objective and subjective measures, with an overall score of 3.6 ± 0.5. Reconstructed images in patients were all diagnostic. Low-dimensional-structure self-learning and thresholding reconstruction allows contrast-enhanced whole-heart coronary MRI with acceleration as high as 4-fold using clinically available five-channel phased-array coil.

Original languageEnglish (US)
Pages (from-to)1434-1443
Number of pages10
JournalMagnetic resonance in medicine
Issue number5
StatePublished - May 2012


  • LOST
  • accelerated imaging
  • compressed sensing
  • contrast-enhanced
  • image reconstruction
  • whole-heart coronary MRI


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