Acacia gum is well tolerated while increasing satiety and lowering peak blood glucose response in healthy human subjects

Riley Larson, Courtney Nelson, Renee Korczak, Holly Willis, Jennifer Erickson, Qi Wang, Joanne Slavin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Acacia gum (AG) is a non-viscous soluble fiber that is easily incorporated into beverages and foods. To determine its physiological effects in healthy human subjects, we fed 0, 20, and 40 g of acacia gum in orange juice along with a bagel and cream cheese after a 12 h fast and compared satiety, glycemic response, gastrointestinal tolerance, and food intake among treatments. Subjects (n = 48) reported less hunger and greater fullness at 15 min (p = 0.019 and 0.003, respectively) and 240 min (p = 0.036 and 0.05, respectively) after breakfast with the 40 g fiber treatment. They also reported being more satisfied at 15 min (p = 0.011) and less hungry with the 40 g fiber treatment at 30 min (p = 0.012). Subjects reported more bloating, flatulence, and GI rumbling on the 40 g fiber treatment compared to control, although values for GI tolerance were all low with AG treatment. No significant differences were found in area under the curve (AUC) or change from baseline for blood glucose response, although actual blood glucose with 20 g fiber at 30 min was significantly less than control. Individuals varied greatly in their postprandial glucose response to all treatments. AG improves satiety response and may lower peak glucose response at certain timepoints, and it is well tolerated in healthy human subjects. AG can be added to beverages and foods in doses that can help meet fiber recommendations.

Original languageEnglish (US)
Article number618
Pages (from-to)1-14
Number of pages14
Issue number2
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This research was funded by Nexira, UMN Award#CON000000075666, Satiety and blood glucose response with acacia gum. Raw data is the dual property of the University of Minnesota and Nexira. The APC was funded by non-sponsored funds from the corresponding author. Qi Wang receives support from the National Center for Advancing Translational Sciences of the National Institutes of Health, Award Number Ul1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright 2021 Elsevier B.V., All rights reserved.


  • Blood glucose
  • Crossover trials
  • Dietary fiber
  • Food intake regulation
  • Gum acacia
  • Gum arabic
  • Healthy subjects
  • Postprandial period
  • Randomized controlled trial
  • Satiety response

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial


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