TY - JOUR
T1 - Abuse in Childhood or Adolescence and Gestational Diabetes
T2 - A Retrospective Cohort Study
AU - Mason, Susan M.
AU - Tobias, Deirdre K.
AU - Clark, Cari J.
AU - Zhang, Cuilin
AU - Hu, Frank B.
AU - Rich-Edwards, Janet W.
N1 - Publisher Copyright:
© 2016 American Journal of Preventive Medicine.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Introduction Early life abuse has been linked to later Type 2 diabetes, but its association with gestational diabetes has not been examined. The aim of this study was to examine the association between childhood and adolescent abuse victimization and risk of gestational diabetes in the Nurses' Health Study II. Methods Participants were asked about experiences of physical and sexual abuse in childhood or adolescence in 2001 and about history of pregnancy complications in 2009. Mothers of singleton live births who provided information on their abuse history comprised the study sample. Modified Poisson regression was used to estimate risk ratios and 95% CIs for gestational diabetes as a function of physical and sexual abuse victimization. Analyses were conducted in 2014-2015. Results Of 45,550 women in the analysis, 8% reported severe physical abuse and 11% reported forced sexual activity in childhood or adolescence. Approximately 3% (n=3,181) of pregnancies were complicated by gestational diabetes. In adjusted models, severe physical abuse was associated with a 42% greater gestational diabetes risk (risk ratio=1.42, 95% CI=1.21, 1.66) relative to no physical abuse. Forced sexual activity was associated with a 30% greater risk (95% CI=1.14, 1.49). Women with histories of both physical and sexual abuse were at higher risk than women exposed to a single type of abuse. These associations were not explained by overweight status in early adulthood or prior to pregnancy. Conclusions Childhood and adolescent victimization is associated with increased risk of gestational diabetes in adult women.
AB - Introduction Early life abuse has been linked to later Type 2 diabetes, but its association with gestational diabetes has not been examined. The aim of this study was to examine the association between childhood and adolescent abuse victimization and risk of gestational diabetes in the Nurses' Health Study II. Methods Participants were asked about experiences of physical and sexual abuse in childhood or adolescence in 2001 and about history of pregnancy complications in 2009. Mothers of singleton live births who provided information on their abuse history comprised the study sample. Modified Poisson regression was used to estimate risk ratios and 95% CIs for gestational diabetes as a function of physical and sexual abuse victimization. Analyses were conducted in 2014-2015. Results Of 45,550 women in the analysis, 8% reported severe physical abuse and 11% reported forced sexual activity in childhood or adolescence. Approximately 3% (n=3,181) of pregnancies were complicated by gestational diabetes. In adjusted models, severe physical abuse was associated with a 42% greater gestational diabetes risk (risk ratio=1.42, 95% CI=1.21, 1.66) relative to no physical abuse. Forced sexual activity was associated with a 30% greater risk (95% CI=1.14, 1.49). Women with histories of both physical and sexual abuse were at higher risk than women exposed to a single type of abuse. These associations were not explained by overweight status in early adulthood or prior to pregnancy. Conclusions Childhood and adolescent victimization is associated with increased risk of gestational diabetes in adult women.
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U2 - 10.1016/j.amepre.2015.08.033
DO - 10.1016/j.amepre.2015.08.033
M3 - Article
C2 - 26547539
AN - SCOPUS:84961167420
SN - 0749-3797
VL - 50
SP - 436
EP - 444
JO - American journal of preventive medicine
JF - American journal of preventive medicine
IS - 4
ER -