Bibliographical noteFunding Information:
Department of Medicinal Chemistry College of Pharmacy University of Minnesota Minneapolis, MN 55455 Received November 15, 1967 Accepted for publication February 9, 1968. This investigation was supported by research grant NB 05192 from the National Institutes of Health. The authors gratefully acknowledge the generosity of Dr. W. E. Scott, Hoffmann-LaRoche. Inc.. for providing a supply of a- and @-prodinea lcohol, and Dr. A. Pohland, Lilly Research Laboratories, for the specimen of ( - )-@-dimethyl-amino-a-methylpropiophenoneh ydrochloride. We also are indebted to Dr. H. Kupferberg of the University of Minnesota for his aid in the pharmacological testing.
- Absolute configuration—analgesic activity
- ED—prodine enantiomers
- IR spectrophotometry—structure
- NMR spectroscopy—structure
- Optical rotation—structure
- Prodine enantiomers—absolute sterochemistry