Absent neutrophil alkaline phosphatase in the eosinophilia myalgia syndrome associated with L‐tryptophan use

Jeffrry P. Jaffe, Elie Gertner, Wesley J Miller

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical constellation of leukocytosis, thrombocytosis, and low or absent stainable neutrophil alkaline phosphatase (NAP) is considered characteristic of chronic myelogenous leukemia (CML) [1]. CML with eosinophilic differentiation (eosinophilic leukemia) is well described [2], and leukemia and other clonal hematologic malignancies are associated with the syndrome of eosinophilic fasciitis [3]. We describe leukocytosis, thrombocytosis, eosinophilia, mild basophilia, and absent stainable NAP, initially suggesting the diagnosis of CML in a patient with the eosinophilia myalgia syndrome associated with L‐tryptophan use, a condition resembling eosinophilic fasciitis. Cytogenetic and molecular genetic studies failed to demonstrate a clonal proliferation of eosinophils.

Original languageEnglish (US)
Pages (from-to)280-281
Number of pages2
JournalAmerican Journal of Hematology
Volume36
Issue number4
DOIs
StatePublished - Apr 1991

Keywords

  • L‐tryptophan
  • eosinophilia
  • neutrophil

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