TY - JOUR
T1 - Absence of placebo response in obsessive-compulsive disorder
AU - Mavissakalian, Matig R.
AU - Jones, Bruce
AU - Olson, Stephen
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990/4
Y1 - 1990/4
N2 - Analyses in 30 patients with a diagnosis of obsessive-compulsive disorder given singleblind placebo over a 2-week period and of 12 of these patients who continued treatment on double-blind placebo for an additional 10 weeks revealed virtual absence of improvement on both clinician and self-rating scales of obsessions, compulsions, phobias, depression, and anxiety. This result would imply that the contribution of the placebo effect to the pharmacotherapy of patients with obsessive-compulsive disorder is negligible although considerable effort and work is still required to reliably identify one of four panic disorder with agoraphobia patients who respond to placebo. The placebo response thus presents a clear distinction between these two phenomenologically complex anxiety disorders.
AB - Analyses in 30 patients with a diagnosis of obsessive-compulsive disorder given singleblind placebo over a 2-week period and of 12 of these patients who continued treatment on double-blind placebo for an additional 10 weeks revealed virtual absence of improvement on both clinician and self-rating scales of obsessions, compulsions, phobias, depression, and anxiety. This result would imply that the contribution of the placebo effect to the pharmacotherapy of patients with obsessive-compulsive disorder is negligible although considerable effort and work is still required to reliably identify one of four panic disorder with agoraphobia patients who respond to placebo. The placebo response thus presents a clear distinction between these two phenomenologically complex anxiety disorders.
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U2 - 10.1097/00005053-199004000-00010
DO - 10.1097/00005053-199004000-00010
M3 - Article
C2 - 2319236
AN - SCOPUS:0025246767
VL - 178
SP - 268
EP - 270
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
SN - 0022-3018
IS - 4
ER -