Absence of cue-evoked firing in rat dorsolateral striatum neurons

David H. Root, Chris C. Tang, Sisi Ma, Anthony P. Pawlak, Mark O. West

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The rat dorsolateral striatum (DLS) has been implicated in habit formation. Previous studies in our laboratory found that as animals acquired a motor habit or remained goal-directed, tested by reward devaluation, the vast majority of DLS neurons decreased firing rates during the same responses over training days. However, mixed results have been reported in the literature regarding whether DLS neurons exhibit cue reactivity. In the present study, we reanalyzed a sample of DLS neurons in a task in which habitual behavior was acquired (dataset of Tang et al., 2007 [45]) and found that somatic sensorimotor as well as nonsomatomotor neurons of the DLS exhibited no cue-evoked firing. A second sample of DLS neurons related to licking in a task in which goal-directed behavior occurred (dataset of Tang et al., 2009 [46]) was also reanalyzed for cue-evoked correlates. Although behavior was cue guided, lick neurons did not exhibit cue-evoked firing. Given the complete absence of cue-related firing during habitual or goal-directed behavior, adaptations in DLS firing patterns may be regulated by movement-related learning rather than nonsomatosensory cues, consistent with convergent S1 and M1 afferents to the region. Striatal cue reactivity in the rat, is likely mediated within the dorsomedial and ventromedial striatum, in line with associative and limbic afferents to these regions, respectively.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalBehavioural Brain Research
Volume211
Issue number1
DOIs
StatePublished - Jul 2010

Bibliographical note

Funding Information:
This study was supported by the National Institute on Drug Abuse Grants DA 006886 , DA 004551 , DA 0026252 . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank David J. Barker, Linda King, Patrick Grace, Kevin Coffey, Harry Ting, Jaya Sandoghar for technical assistance.

Keywords

  • Accumbens
  • Conditioned stimulus
  • Habit
  • Putamen
  • Response
  • Stimulus
  • Striatum

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