Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes

Charles R. Jonassaint, Jin Peng Szatkiewicz, Cynthia M. Bulik, Laura M. Thornton, Cinnamon Bloss, Wade H. Berrettini, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Michael Strober, Pamela K. Keel, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. Kaplan, Kelly L. KlumpMaria La Via, James E. Mitchell, Alessandro Rotondo, Janet Treasure, D. Blake Woodside

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume156
Issue number4
DOIs
StatePublished - Jun 1 2011

Fingerprint

Obesity
Psychology
Single Nucleotide Polymorphism
Phenotype
Anorexia Nervosa
Feeding Behavior
Weights and Measures
Genes
Pathology
Impulsive Behavior
Genome-Wide Association Study
Population
Anxiety
Feeding and Eating Disorders

Keywords

  • BMI
  • FTO
  • SNPs

Cite this

Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes. / Jonassaint, Charles R.; Szatkiewicz, Jin Peng; Bulik, Cynthia M.; Thornton, Laura M.; Bloss, Cinnamon; Berrettini, Wade H.; Kaye, Walter H.; Bergen, Andrew W.; Magistretti, Pierre; Strober, Michael; Keel, Pamela K.; Brandt, Harry; Crawford, Steve; Crow, Scott; Fichter, Manfred M.; Goldman, David; Halmi, Katherine A.; Johnson, Craig; Kaplan, Allan S.; Klump, Kelly L.; La Via, Maria; Mitchell, James E.; Rotondo, Alessandro; Treasure, Janet; Woodside, D. Blake.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 156, No. 4, 01.06.2011, p. 454-461.

Research output: Contribution to journalArticle

Jonassaint, CR, Szatkiewicz, JP, Bulik, CM, Thornton, LM, Bloss, C, Berrettini, WH, Kaye, WH, Bergen, AW, Magistretti, P, Strober, M, Keel, PK, Brandt, H, Crawford, S, Crow, S, Fichter, MM, Goldman, D, Halmi, KA, Johnson, C, Kaplan, AS, Klump, KL, La Via, M, Mitchell, JE, Rotondo, A, Treasure, J & Woodside, DB 2011, 'Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156, no. 4, pp. 454-461. https://doi.org/10.1002/ajmg.b.31182
Jonassaint, Charles R. ; Szatkiewicz, Jin Peng ; Bulik, Cynthia M. ; Thornton, Laura M. ; Bloss, Cinnamon ; Berrettini, Wade H. ; Kaye, Walter H. ; Bergen, Andrew W. ; Magistretti, Pierre ; Strober, Michael ; Keel, Pamela K. ; Brandt, Harry ; Crawford, Steve ; Crow, Scott ; Fichter, Manfred M. ; Goldman, David ; Halmi, Katherine A. ; Johnson, Craig ; Kaplan, Allan S. ; Klump, Kelly L. ; La Via, Maria ; Mitchell, James E. ; Rotondo, Alessandro ; Treasure, Janet ; Woodside, D. Blake. / Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2011 ; Vol. 156, No. 4. pp. 454-461.
@article{aeebf8a0a5d3468488655eb726fc1fbd,
title = "Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes",
abstract = "Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.",
keywords = "BMI, FTO, SNPs",
author = "Jonassaint, {Charles R.} and Szatkiewicz, {Jin Peng} and Bulik, {Cynthia M.} and Thornton, {Laura M.} and Cinnamon Bloss and Berrettini, {Wade H.} and Kaye, {Walter H.} and Bergen, {Andrew W.} and Pierre Magistretti and Michael Strober and Keel, {Pamela K.} and Harry Brandt and Steve Crawford and Scott Crow and Fichter, {Manfred M.} and David Goldman and Halmi, {Katherine A.} and Craig Johnson and Kaplan, {Allan S.} and Klump, {Kelly L.} and {La Via}, Maria and Mitchell, {James E.} and Alessandro Rotondo and Janet Treasure and Woodside, {D. Blake}",
year = "2011",
month = "6",
day = "1",
doi = "10.1002/ajmg.b.31182",
language = "English (US)",
volume = "156",
pages = "454--461",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes

AU - Jonassaint, Charles R.

AU - Szatkiewicz, Jin Peng

AU - Bulik, Cynthia M.

AU - Thornton, Laura M.

AU - Bloss, Cinnamon

AU - Berrettini, Wade H.

AU - Kaye, Walter H.

AU - Bergen, Andrew W.

AU - Magistretti, Pierre

AU - Strober, Michael

AU - Keel, Pamela K.

AU - Brandt, Harry

AU - Crawford, Steve

AU - Crow, Scott

AU - Fichter, Manfred M.

AU - Goldman, David

AU - Halmi, Katherine A.

AU - Johnson, Craig

AU - Kaplan, Allan S.

AU - Klump, Kelly L.

AU - La Via, Maria

AU - Mitchell, James E.

AU - Rotondo, Alessandro

AU - Treasure, Janet

AU - Woodside, D. Blake

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.

AB - Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.

KW - BMI

KW - FTO

KW - SNPs

UR - http://www.scopus.com/inward/record.url?scp=79955092983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955092983&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.31182

DO - 10.1002/ajmg.b.31182

M3 - Article

C2 - 21438147

AN - SCOPUS:79955092983

VL - 156

SP - 454

EP - 461

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 4

ER -