About 8-hour variation of circulating human endothelin-1

Manfred Herold, Germaine Cornélissen, Alexander Loeckinger, Dieter Koeberle, Paul Koenig, Franz Halberg

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Plasma endothelin-1 (ET-1) and cortisol were measured around the clock at hourly intervals on 7 clinically healthy, diurnally active, nocturnally resting subjects 22-27 years of age. The circadian rhythm in cortisol is demonstrated for each subject (p ≤ 0.020) as well as on a group basis (p = 0.002), peaking in the morning. By contrast, the circadian variation of ET-1 is statistically significant in only one of the subjects, and it is not detected for the group as a whole (p > 0.20). Instead, ET-1 is characterized by an about 8-h component (p < 0.001) that is not found for cortisol.

Original languageEnglish (US)
Pages (from-to)821-825
Number of pages5
Issue number5
StatePublished - May 1998


  • Circadian
  • Circaoctohoran
  • ET- 1


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