About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma

G. S. Katinas, F. Halberg, Germaine G Cornelissen-Guillaume, Douglas M Hawkins, M. V. Bueva, D. E. Korzhevsky, L. R. Sapozhnikova, Nelson L Rhodus, E. Schaffer

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Population densities (PD) of capillaries (C) and endotheliocytes (E) were determined in pinnal dermis of C57BL mice before and after trauma. Moving (and overall) least-squares spectra before trauma detected in EPD (versus CPD) pronounced 3.5-day (circasemiseptan) and 8-h oscillations corresponding to components of the endothelin-1 chronome in human blood plasma reported earlier. Circadians were more pronounced in CPD. After trauma, circasemiseptan oscillations appeared also in CPD; their period gradually shortened and in two weeks split into about 2.5- and about 4.5-day oscillations; and circadian components became very pronounced. The pre-traumatic chronome was not restored within three weeks following trauma.

Original languageEnglish (US)
Pages (from-to)647-659
Number of pages13
JournalPeptides
Volume22
Issue number4
DOIs
StatePublished - Apr 30 2001

Keywords

  • Capillaries
  • Chronome
  • Circadian
  • Circasemiseptan
  • ET-1
  • Endotheliocytes
  • Population density
  • Regeneration
  • Trauma

Fingerprint Dive into the research topics of 'About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma'. Together they form a unique fingerprint.

  • Cite this

    Katinas, G. S., Halberg, F., Cornelissen-Guillaume, G. G., Hawkins, D. M., Bueva, M. V., Korzhevsky, D. E., Sapozhnikova, L. R., Rhodus, N. L., & Schaffer, E. (2001). About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma. Peptides, 22(4), 647-659. https://doi.org/10.1016/S0196-9781(01)00375-8