About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma

G. S. Katinas, F. Halberg, Germaine G Cornelissen-Guillaume, Douglas M Hawkins, M. V. Bueva, D. E. Korzhevsky, L. R. Sapozhnikova, Nelson L Rhodus, E. Schaffer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Population densities (PD) of capillaries (C) and endotheliocytes (E) were determined in pinnal dermis of C57BL mice before and after trauma. Moving (and overall) least-squares spectra before trauma detected in EPD (versus CPD) pronounced 3.5-day (circasemiseptan) and 8-h oscillations corresponding to components of the endothelin-1 chronome in human blood plasma reported earlier. Circadians were more pronounced in CPD. After trauma, circasemiseptan oscillations appeared also in CPD; their period gradually shortened and in two weeks split into about 2.5- and about 4.5-day oscillations; and circadian components became very pronounced. The pre-traumatic chronome was not restored within three weeks following trauma.

Original languageEnglish (US)
Pages (from-to)647-659
Number of pages13
Issue number4
StatePublished - 2001


  • Capillaries
  • Chronome
  • Circadian
  • Circasemiseptan
  • ET-1
  • Endotheliocytes
  • Population density
  • Regeneration
  • Trauma


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