ABO blood group, other risk factors and incidence of venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)

T. Ohira, M. Cushman, M. Y. Tsai, Y. Zhang, S. R. Heckbert, N. A. Zakai, W. D. Rosamond, Aaron R. Folsom

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

Background: Numerous case-control studies have reported higher prevalence of non-O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established. Patients/methods: Using a nested case-control design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, ABO blood type and other VTE risk factors were measured on pre-event blood samples of 492 participants who subsequently developed VTE and 1008 participants who remained free of VTE. Results: A total of64.4% of cases and 52.5% of controls had non-O blood type. Among controls, mean values of factor VIIIc (FVIIIc) and von Willebrand factor among the non-O blood type group were higher than among the O group. Compared with O blood type, the age-adjusted odds ratio (OR) of VTE for non-O blood type was 1.64 (95% CI, 1.32-2.05) and was similar for the two parent studies and race groups. Further adjustment for sex, race, body mass index, diabetes mellitus and FVIIIc reduced the OR: 1.31 (95% CI, 1.02-1.68). Factor V Leiden (FV Leiden) appeared to modify the non-O blood type association with VTE in a supra-additive fashion, with an age-, sex- and race-adjusted OR of 6.77 (95% CI, 3.65-12.6) for having both risk factors. Conclusions: Non-O blood type was independently associated with risk of VTE, and added to the risk associated with FV Leiden.

Original languageEnglish (US)
Pages (from-to)1455-1461
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • Blood type
  • Coagulation factor
  • Epidemiology
  • Risk factors
  • Venous thrombosis

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