Background: In sickle cell disease (SCD), pulmonary hypertension (assessed by tricuspid regurgitant jet [TRJ] velocity ≥ 2.5 m/sec) is associated with increased mortality. The relationships among TRJ velocity and left ventricular (LV) and right ventricular (RV) systolic and diastolic function (i.e., relaxation and compliance) have not been well characterized in SCD. Methods: A prospective study was conducted in 53 ambulatory adults with SCD (mean age, 34 years; range, 21-65 years) and 33 African American controls to define the relationship between LV and RV function and TRJ velocity using echocardiography. Results: Subjects with SCD had larger left and right atrial volumes and increased LV mass compared with controls. When patients with SCD were compared with controls, LV and RV relaxation (i.e., E′) were similar. Among subjects with SCD, pulmonary hypertension (TRJ ≥ 2.5 m/sec) was present in 40%. Higher TRJ velocity was correlated with larger left atrial volumes in patients with SCD. Additionally, some measures of LV (peak A, lateral and septal annular E/E′ ratio) and RV (tricuspid valve E/E′ ratio) compliance were correlated with TRJ velocity. No other measures of LV and RV systolic function or LV diastolic function (i.e., relaxation and compliance) were associated with TRJ velocity. Conclusions: Ambulatory adults with SCD exhibited structural (i.e., LV and RV chamber enlargement) and functional (i.e., higher surrogate measures of LV and RV filling pressure) abnormalities compared with the control group. In subjects with SCD, few abnormalities of LV and RV structure and function were associated with TRJ velocity.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of the American Society of Echocardiography|
|State||Published - Nov 2011|
Bibliographical noteFunding Information:
This study was supported in part by awards K12HL08710 (J.J.F.), KL2RR024994 (L.F.), and UL1RR024992 (J.J.F. and L.F.) from the National Heart, Lung, and Blood Institute (Bethesda, MD) and the award 2004061 (J.K.P.) from the Doris Duke Charitable Foundation (New York, NY).
- Diastolic dysfunction
- Pulmonary hypertension
- Sickle cell disease