Abnormalities in biomarkers of mineral and bone metabolism in kidney donors

Bertram L. Kasiske; Rajiv Kumar; Paul L. Kimmel; Todd E. Pesavento; Roberto S. Kalil; Edward S. Kraus; Hamid Rabb; Andrew M. Posselt; Teresa L. Anderson-Haag; Michael W. Steffes; Ajay K. Israni; Jon J. Snyder; Ravinder J. Singh; Matthew R. Weir

doi:10.1016/j.kint.2016.05.012

Abnormalities in biomarkers of mineral and bone metabolism in kidney donors

Bertram L. Kasiske, Rajiv Kumar, Paul L. Kimmel, Todd E. Pesavento, Roberto S. Kalil, Edward S. Kraus, Hamid Rabb, Andrew M. Posselt, Teresa L. Anderson-Haag, Michael W. Steffes, Ajay K. Israni, Jon J. Snyder, Ravinder J. Singh, Matthew R. Weir

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (–7.0% and –5.0%) and serum phosphate concentrations (–6.4% and –2.3%). Serum 1,25-dihydroxyvitamin D₃ concentrations were significantly lower (–17.1% and –12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.

Original language	English (US)
Pages (from-to)	861-868
Number of pages	8
Journal	Kidney international
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.kint.2016.05.012
State	Published - Oct 1 2016

Bibliographical note

Funding Information:
This study was funded by the National Institutes of Health under the cooperative agreement U01-DK066013. The National Institutes of Health participated in the interpretation of data, the writing of the report, and the decision to submit the report for publication. The opinions expressed herein do not necessarily reflect those of the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, the Department of Health and Human Services, or the government of the United States.

Publisher Copyright:
© 2016 International Society of Nephrology

Keywords

FGF23
hyperparathyroidism
mineral metabolism
parathyroid hormone

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10.1016/j.kint.2016.05.012

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Kasiske, B. L., Kumar, R., Kimmel, P. L., Pesavento, T. E., Kalil, R. S., Kraus, E. S., Rabb, H., Posselt, A. M., Anderson-Haag, T. L., Steffes, M. W., Israni, A. K., Snyder, J. J., Singh, R. J., & Weir, M. R. (2016). Abnormalities in biomarkers of mineral and bone metabolism in kidney donors. Kidney international, 90(4), 861-868. https://doi.org/10.1016/j.kint.2016.05.012

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title = "Abnormalities in biomarkers of mineral and bone metabolism in kidney donors",

abstract = "Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (–7.0% and –5.0%) and serum phosphate concentrations (–6.4% and –2.3%). Serum 1,25-dihydroxyvitamin D3 concentrations were significantly lower (–17.1% and –12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.",

keywords = "FGF23, hyperparathyroidism, mineral metabolism, parathyroid hormone",

author = "Kasiske, {Bertram L.} and Rajiv Kumar and Kimmel, {Paul L.} and Pesavento, {Todd E.} and Kalil, {Roberto S.} and Kraus, {Edward S.} and Hamid Rabb and Posselt, {Andrew M.} and Anderson-Haag, {Teresa L.} and Steffes, {Michael W.} and Israni, {Ajay K.} and Snyder, {Jon J.} and Singh, {Ravinder J.} and Weir, {Matthew R.}",

note = "Funding Information: This study was funded by the National Institutes of Health under the cooperative agreement U01-DK066013. The National Institutes of Health participated in the interpretation of data, the writing of the report, and the decision to submit the report for publication. The opinions expressed herein do not necessarily reflect those of the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, the Department of Health and Human Services, or the government of the United States. Publisher Copyright: {\textcopyright} 2016 International Society of Nephrology",

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doi = "10.1016/j.kint.2016.05.012",

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AU - Kasiske, Bertram L.

AU - Kumar, Rajiv

AU - Kimmel, Paul L.

AU - Pesavento, Todd E.

AU - Kalil, Roberto S.

AU - Kraus, Edward S.

AU - Rabb, Hamid

AU - Posselt, Andrew M.

AU - Anderson-Haag, Teresa L.

AU - Steffes, Michael W.

AU - Israni, Ajay K.

AU - Snyder, Jon J.

AU - Singh, Ravinder J.

AU - Weir, Matthew R.

N1 - Funding Information: This study was funded by the National Institutes of Health under the cooperative agreement U01-DK066013. The National Institutes of Health participated in the interpretation of data, the writing of the report, and the decision to submit the report for publication. The opinions expressed herein do not necessarily reflect those of the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, the Department of Health and Human Services, or the government of the United States. Publisher Copyright: © 2016 International Society of Nephrology

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (–7.0% and –5.0%) and serum phosphate concentrations (–6.4% and –2.3%). Serum 1,25-dihydroxyvitamin D3 concentrations were significantly lower (–17.1% and –12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.

AB - Previous studies have suggested that kidney donors may have abnormalities of mineral and bone metabolism typically seen in chronic kidney disease. This may have important implications for the skeletal health of living kidney donors and for our understanding of the pathogenesis of long-term mineral and bone disorders in chronic kidney disease. In this prospective study, 182 of 203 kidney donors and 173 of 201 paired normal controls had markers of mineral and bone metabolism measured before and at 6 and 36 months after donation (ALTOLD Study). Donors had significantly higher serum concentrations of intact parathyroid hormone (24.6% and 19.5%) and fibroblast growth factor-23 (9.5% and 8.4%) at 6 and 36 months, respectively, as compared to healthy controls, and significantly reduced tubular phosphate reabsorption (–7.0% and –5.0%) and serum phosphate concentrations (–6.4% and –2.3%). Serum 1,25-dihydroxyvitamin D3 concentrations were significantly lower (–17.1% and –12.6%), while 25-hydroxyvitamin D (21.4% and 19.4%) concentrations were significantly higher in donors compared to controls. Moreover, significantly higher concentrations of the bone resorption markers, carboxyterminal cross-linking telopeptide of bone collagen (30.1% and 13.8%) and aminoterminal cross-linking telopeptide of bone collagen (14.2% and 13.0%), and the bone formation markers, osteocalcin (26.3% and 2.7%) and procollagen type I N-terminal propeptide (24.3% and 8.9%), were observed in donors. Thus, kidney donation alters serum markers of bone metabolism that could reflect impaired bone health. Additional long-term studies that include assessment of skeletal architecture and integrity are warranted in kidney donors.

KW - FGF23

KW - hyperparathyroidism

KW - mineral metabolism

KW - parathyroid hormone

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Abnormalities in biomarkers of mineral and bone metabolism in kidney donors

Abstract

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