Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

Yann Lamarre, Stéphane Petres, Marie Dominique Hardy-Dessources, Stéphane Sinnapah, Marc Romana, Sandrine Laurance, Nathalie Lemonne, Jürg Gysin, Philippe Connes

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalClinical hemorheology and microcirculation
Volume51
Issue number3
DOIs
StatePublished - Jul 23 2012

Keywords

  • Sickle red cells
  • flow adhesion
  • pregnancy complications

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