Abnormal cortical neural synchrony during working memory in schizophrenia

Seung Suk Kang, Angus W. MacDonald, Matthew V. Chafee, Chang Hwan Im, Edward M. Bernat, Nicholas D. Davenport, Scott R. Sponheim

Research output: Research - peer-reviewArticle

Abstract

Objective To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information. Methods We examined time–frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM−related hemodynamic responses and individualized structural head-models. Results Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM−load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices. Conclusions Although beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia. Significance Time-frequency-spatial analysis identified process- and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia.

LanguageEnglish (US)
Pages210-221
Number of pages12
JournalClinical Neurophysiology
Volume129
Issue number1
DOIs
StatePublished - Jan 1 2018

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Short-Term Memory
Schizophrenia
Visual Cortex
Maintenance
Parietal Lobe
Magnetoencephalography
Spatial Analysis
Structural Models
Memory Disorders
Prefrontal Cortex
Hemodynamics
Head

Keywords

  • Cortical source analysis
  • Magnetoencephalography (MEG)
  • Neural oscillation
  • Schizophrenia
  • Working memory

Cite this

Abnormal cortical neural synchrony during working memory in schizophrenia. / Kang, Seung Suk; MacDonald, Angus W.; Chafee, Matthew V.; Im, Chang Hwan; Bernat, Edward M.; Davenport, Nicholas D.; Sponheim, Scott R.

In: Clinical Neurophysiology, Vol. 129, No. 1, 01.01.2018, p. 210-221.

Research output: Research - peer-reviewArticle

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abstract = "Objective To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information. Methods We examined time–frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM−related hemodynamic responses and individualized structural head-models. Results Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM−load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices. Conclusions Although beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia. Significance Time-frequency-spatial analysis identified process- and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia.",
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