Ablative surgery and deep brain stimulation for Parkinson's disease

Philip A. Starr, Jerrold L. Vitek, Roy A.E. Bakay

Research output: Contribution to journalReview article

176 Citations (Scopus)

Abstract

SURGICAL OPTIONS FOR Parkinson's disease (PD) are rapidly expanding and include ablative procedures, deep brain stimulation, and cell transplantation. The target nuclei for ablative surgery and deep brain stimulation are the motor thalamus, the globus pallidus, and the subthalamic nucleus. Multiple factors have led to the resurgence of interest in the surgical treatment of PD: 1) recognition that long-term medical therapy for PD is often unsatisfactory, with patients eventually suffering from drug- induced dyskinesias, motor fluctuations, and variable responses to medication; 2) greater understanding of the pathophysiology of PD, providing a better scientific rationale for some previously developed procedures and suggesting new targets; and 3) use of improved techniques, such as computed tomography- and magnetic resonance imaging-guided stereotaxy and single-unit microelectrode recording, making surgical intervention in the basal ganglia more precise. We review the present status of ablative surgery and deep brain stimulation for PD, including theoretical aspects, surgical techniques, and clinical results.

Original languageEnglish (US)
Pages (from-to)989-1013
Number of pages25
JournalNeurosurgery
Volume43
Issue number5
DOIs
StatePublished - Nov 1 1998

Fingerprint

Deep Brain Stimulation
Parkinson Disease
Drug-Induced Dyskinesia
Subthalamic Nucleus
Globus Pallidus
Cell Transplantation
Microelectrodes
Basal Ganglia
Thalamus
Tomography
Magnetic Resonance Imaging
Therapeutics

Keywords

  • Basal ganglia
  • Electrical stimulation therapy
  • Globus pallidus
  • Parkinson's disease
  • Stereotactic techniques
  • Thalamus

Cite this

Ablative surgery and deep brain stimulation for Parkinson's disease. / Starr, Philip A.; Vitek, Jerrold L.; Bakay, Roy A.E.

In: Neurosurgery, Vol. 43, No. 5, 01.11.1998, p. 989-1013.

Research output: Contribution to journalReview article

Starr, Philip A. ; Vitek, Jerrold L. ; Bakay, Roy A.E. / Ablative surgery and deep brain stimulation for Parkinson's disease. In: Neurosurgery. 1998 ; Vol. 43, No. 5. pp. 989-1013.
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