Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin

Naomi Courtemanche, Stacey M. Gifford, Mark A. Simpson, Thomas D. Pollard, Anthony J. Koleske

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: Arg/Abl2 has two actin-binding domains, but how they influence actin filaments was unknown. Results: Arg and cortactin cooperatively stabilize actin filaments; Arg enhances Arp2/3 complex activation and stimulates severing by cofilin. Conclusion: Arg directly regulates actin filament stability, branching, and severing, which are modulated by cortactin. Significance: These activities may underlie the control of actin-based cellular structures by Arg.

Original languageEnglish (US)
Pages (from-to)4038-4046
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

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