Aberrant Immunity: The Consequences of Overreacting or Underperforming

E. John Wherry, David Masopust

Research output: Chapter in Book/Report/Conference proceedingChapter


Aberrant immunity refers to the ability of selected viruses to perturb the adaptive immune response in either of two distinct ways. On the one hand, the virus-specific immune response can cause pathological lesions, while on the other some viruses can suppress or sabotage adaptive immunity. How is this possible and how does it square with the protective action of adaptive immunity? In this chapter, we will present the evidence for these counterintuitive outcomes, explore their mechanisms, and describe examples of human viral diseases caused by aberrant immune responses.

Original languageEnglish (US)
Title of host publicationViral Pathogenesis
Subtitle of host publicationFrom Basics to Systems Biology: Third Edition
PublisherElsevier Inc.
Number of pages9
ISBN (Print)9780128009642
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.


  • Aberrant immunity
  • CTLs
  • Cell-mediated cytolysis
  • Immunity
  • LCMV
  • Persistent infection
  • Virus-induced immunopathology
  • Virus-induced immunosuppression


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