Abstract
Aberrant immunity refers to the ability of selected viruses to perturb the adaptive immune response in either of two distinct ways. On the one hand, the virus-specific immune response can cause pathological lesions, while on the other some viruses can suppress or sabotage adaptive immunity. How is this possible and how does it square with the protective action of adaptive immunity? In this chapter, we will present the evidence for these counterintuitive outcomes, explore their mechanisms, and describe examples of human viral diseases caused by aberrant immune responses.
| Original language | English (US) |
|---|---|
| Title of host publication | Viral Pathogenesis |
| Subtitle of host publication | From Basics to Systems Biology: Third Edition |
| Publisher | Elsevier Inc. |
| Pages | 71-79 |
| Number of pages | 9 |
| ISBN (Print) | 9780128009642 |
| DOIs | |
| State | Published - 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd. All rights reserved.
Keywords
- Aberrant immunity
- CTLs
- Cell-mediated cytolysis
- Immunity
- LCMV
- Persistent infection
- Virus-induced immunopathology
- Virus-induced immunosuppression