Abdominal aortic aneurysm events in the women's health initiative: Cohort study

Frank A. Lederle, Joseph C. Larson, Karen L. Margolis, Matthew A. Allison, Matthew S. Freiberg, Barbara B. Cochrane, William F. Graettinger, J. David Curb

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Objective: To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women. Design: Large prospective observational cohort study with mean follow-up of 7.8 years. Setting: 40 clinical centres across the United States. Participants: 161 808 postmenopausal women aged 50-79 enrolled in the women's health initiative. Main outcome measures: Association of self reported or measured baseline variables with confirmed abdominal aortic aneurysm events assessed with multiple logistic regression. Results: Events occurred in 184 women and were strongly associated with age and smoking. Ever smoking, current smoking, and amount smoked all contributed independent risk. Diabetes showed a negative association (odds ratio 0.29, 95% confidence interval 0.13, 0.68), as did postmenopausal hormone therapy. Positive associations were also seen for height, hypertension, cholesterol lowering treatment, and coronary and peripheral artery disease. Conclusions: Our findings confirm the strong positive associations of clinically important abdominal aortic aneurysm with age and smoking in women and the negative association with diabetes previously reported in men.

Original languageEnglish (US)
Pages (from-to)1037-1040
Number of pages4
Issue number7677
StatePublished - Nov 1 2008


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