Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project

Andrea A. Florio, Peter T. Campbell, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Jean Wactawski-Wende, Stephanie A. Smith-Warner, Rashmi Sinha, Tracey G. Simon, Howard D. Sesso, Catherine Schairer, Lynn Rosenberg, Thomas E. Rohan, Kim Robien, Andrew G. Renehan, Mark P. Purdue, Jenny N. Poynter, Julie R. Palmer, Christina C. Newton, Yunxia Lu, Martha S. LinetLinda M. Liao, I. Min Lee, Jill Koshiol, Cari M. Kitahara, Victoria A. Kirsh, Jonathan N. Hofmann, Barry I. Graubard, Edward Giovannucci, John M. Gaziano, Susan M. Gapstur, Neal D. Freedman, Jane Demuth, Dawn Q. Chong, Andrew T. Chan, Julie E. Buring, Patrick T. Bradshaw, Laura E. Beane Freeman, Katherine A. McGlynn, Jessica L. Petrick

Research output: Contribution to journalArticle

Abstract

Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type—hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC n = 1,154, ICC n = 335). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Waist circumference, per 5 cm increase, was associated with an 11% increased PLC risk (HR = 1.11, 95%CI: 1.09–1.14), including when adjusted for hip circumference (HR = 1.12, 95%CI: 1.08–1.17) and also when restricted to individuals in a normal body mass index (BMI) range (18.5 to <25 kg/m2; HR = 1.14, 95%CI: 1.07–1.21). Hip circumference, per 5 cm increase, was associated with a 9% increased PLC risk (HR = 1.09, 95%CI: 1.06–1.12), but no association remained after adjustment for waist circumference (HR = 0.99, 95%CI: 0.94–1.03). HCC and ICC results were similar. These findings suggest that excess abdominal size is associated with an increased risk of liver cancer, even among individuals considered to have a normal BMI. However, excess gluteofemoral size alone confers no increased risk. Our findings extend prior analyses, which found an association between excess adiposity and risk of liver cancer, by disentangling the separate effects of excess abdominal and gluteofemoral size through utilization of both waist and hip circumference measurements.

Original languageEnglish (US)
Pages (from-to)675-685
Number of pages11
JournalInternational Journal of Cancer
Volume147
Issue number3
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • abdominal obesity
  • epidemiology
  • gluteofemoral obesity
  • hepatocellular carcinoma
  • intrahepatic cholangiocarcinoma

Fingerprint Dive into the research topics of 'Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project'. Together they form a unique fingerprint.

  • Cite this

    Florio, A. A., Campbell, P. T., Zhang, X., Zeleniuch-Jacquotte, A., Wactawski-Wende, J., Smith-Warner, S. A., Sinha, R., Simon, T. G., Sesso, H. D., Schairer, C., Rosenberg, L., Rohan, T. E., Robien, K., Renehan, A. G., Purdue, M. P., Poynter, J. N., Palmer, J. R., Newton, C. C., Lu, Y., ... Petrick, J. L. (Accepted/In press). Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project. International Journal of Cancer, 147(3), 675-685. https://doi.org/10.1002/ijc.32760