Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents

Justin R. Ryder, Sonia Vega-López, Constantine S. Djedjos, Gabriel Q. Shaibi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R§ssup§2§esup§ = 0.13, β = -1.7; p = 0.006; R§ssup§2§esup§ = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R§ssup§2§ esup§ = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.

Original languageEnglish (US)
Article number72
JournalDiabetology and Metabolic Syndrome
Issue number1
StatePublished - 2013
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Salt River Pima Maricopa Indian Community, Health Research Alliance Arizona, Phoenix Children’s Hospital, and the Mayo/ ASU Center for Metabolic and Vascular Biology. Data management support was provided by Grant UL1-RR-024150 from the Mayo Clinic to use Research Electronic Data Capture (REDCap). The authors are grateful to the children and their families who participated in this study.


  • Abdominal obesity
  • Insulin resistance
  • Latino adolescents
  • Metabolic syndrome
  • Oxidized LDL


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