Abdominal adiposity and hot flashes among midlife women

Rebecca C. Thurston, MaryFran R. Sowers, Kim Sutton-Tyrrell, Susan A. Everson-Rose, Tené T. Lewis, Daniel Edmundowicz, Karen A. Matthews

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

OBJECTIVE: Two competing hypotheses suggest how adiposity may affect menopausal hot flashes. The "thin hypothesis" asserts that aromatization of androgens to estrogens in body fat should be associated with decreased hot flashes. Conversely, thermoregulatory models argue that body fat should be associated with increased hot flashes. The study objective was to examine associations between abdominal adiposity and hot flashes, including the role of reproductive hormones in these associations. DESIGN: The Study of Women's Health Across the Nation Heart Study (2001-2003) is an ancillary study to the Study of Women's Health Across the Nation, a community-based cohort study. Participants were 461 women (35% African American, 65% white) ages 45 to 58 years with an intact uterus and at least one ovary. Measures included a computed tomography scan to assess abdominal adiposity; reported hot flashes over the previous 2 weeks; and a blood sample for measurement of follicle-stimulating hormone, estradiol, and sex hormone-binding globulin-adjusted estradiol (free estradiol index). Associations were evaluated within multivariable logistic and linear regression models. RESULTS: Every 1-SD increase in total (odds ratio [OR] = 1.28; 95% CI: 1.06-1.55) and subcutaneous (OR = 1.30; 95% CI: 1.07-1.58) abdominal adiposity was associated with increased odds of hot flashes in age- and site-adjusted models. Visceral adiposity was not associated with hot flashes. Associations were not reduced when models included reproductive hormone concentrations. CONCLUSION: Increased abdominal adiposity, particularly subcutaneous adiposity, is associated with increased odds of hot flashes, favoring thermoregulatory models of hot flashes. Body fat may not protect women from hot flashes as once thought.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalMenopause
Volume15
Issue number3
DOIs
StatePublished - May 1 2008

Fingerprint

Hot Flashes
Adiposity
Adipose Tissue
Estradiol
Women's Health
Linear Models
Odds Ratio
Hormones
Sex Hormone-Binding Globulin
Follicle Stimulating Hormone
African Americans
Androgens
Uterus
Ovary
Estrogens
Cohort Studies
Logistic Models
Tomography

Keywords

  • Abdominal adiposity
  • Body fat
  • Central adiposity
  • Hot flashes
  • Menopause
  • Vasomotor symptoms

Cite this

Thurston, R. C., Sowers, M. R., Sutton-Tyrrell, K., Everson-Rose, S. A., Lewis, T. T., Edmundowicz, D., & Matthews, K. A. (2008). Abdominal adiposity and hot flashes among midlife women. Menopause, 15(3), 429-434. https://doi.org/10.1097/gme.0b013e31815879cf

Abdominal adiposity and hot flashes among midlife women. / Thurston, Rebecca C.; Sowers, MaryFran R.; Sutton-Tyrrell, Kim; Everson-Rose, Susan A.; Lewis, Tené T.; Edmundowicz, Daniel; Matthews, Karen A.

In: Menopause, Vol. 15, No. 3, 01.05.2008, p. 429-434.

Research output: Contribution to journalArticle

Thurston, RC, Sowers, MR, Sutton-Tyrrell, K, Everson-Rose, SA, Lewis, TT, Edmundowicz, D & Matthews, KA 2008, 'Abdominal adiposity and hot flashes among midlife women', Menopause, vol. 15, no. 3, pp. 429-434. https://doi.org/10.1097/gme.0b013e31815879cf
Thurston RC, Sowers MR, Sutton-Tyrrell K, Everson-Rose SA, Lewis TT, Edmundowicz D et al. Abdominal adiposity and hot flashes among midlife women. Menopause. 2008 May 1;15(3):429-434. https://doi.org/10.1097/gme.0b013e31815879cf
Thurston, Rebecca C. ; Sowers, MaryFran R. ; Sutton-Tyrrell, Kim ; Everson-Rose, Susan A. ; Lewis, Tené T. ; Edmundowicz, Daniel ; Matthews, Karen A. / Abdominal adiposity and hot flashes among midlife women. In: Menopause. 2008 ; Vol. 15, No. 3. pp. 429-434.
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