Abbreviated chemotherapy for limited-stage diffuse large B-cell lymphoma after complete resection

Jungmin Jo, Dok Hyun Yoon, Sang Wook Lee, Chan Sik Park, Jooryung Huh, Kyoungmin Lee, Eun Hee Kang, Shin Kim, Cheolwon Suh

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1 Scopus citations

Abstract

Background: Abbreviated chemotherapy followed by radiotherapy or full cycles of chemotherapy is recommended as a standard treatment for limited-stage (LS) diffuse large B-cell lymphoma (DLBCL). After complete resection of tumors, however, Burkitt and childhood B-cell Non-Hodgkin lymphoma show favorable outcomes, even after abbreviated chemotherapy of only 2 or 3 cycles. We investigated the effectiveness of abbreviated chemotherapy in patients with LS DLBCL after complete tumor resection. Methods: We retrospectively reviewed 18 patients with LS DLBCL who underwent complete tumor resection followed by either 3 or 4 cycles of chemotherapy between March 2002 and May 2010. Results: With a median follow-up period of 57.9 months (range, 31.8-130.2 months), no patients experienced disease relapse or progression; however, 1 patient experienced secondary acute myeloid leukemia during follow-up. The 5-year progression-free survival rate and overall survival rate were 93.3% and 94.1%, respectively. Conclusion: These results warrant further investigation into abbreviated chemotherapy as an alternative treatment for patients who have undergone complete resection of LS DLBCL.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalBlood Research
Volume49
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Abbreviated chemotherapy
  • Diffuse large B-cell lymphoma
  • Limited stage
  • Resection

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