A water-mediated allosteric network governs activation of Aurora kinase A

Keyphrases

• Aurora Kinase A (AURKA) 100%
• Allosteric Network 100%
• TPX2 100%
• Aurora A 100%
• Water-mediated 100%
• Protein Kinase 66%
• DFG Motif 66%
• Water Network 66%
• Associated Proteins 33%
• Phosphorylation 33%
• Spine 33%
• Allosteric Activation 33%
• Spindle 33%
• Active Sites 33%
• Conformational Change 33%
• Tightly Coupled 33%
• Hydrogen Bond Network 33%
• Catalytic Activity 33%
• Nanometer Scale 33%
• Transfer Test 33%
• Förster Resonance Energy Transfer 33%
• Equilibrium Shift 33%
• Activation Loop 33%
• Residue Network 33%
• Mitotic Kinases 33%
• Infrared Probe 33%
• C-helix 33%
• Water-mediated Hydrogen Bonds 33%
• Regulatory Spine 33%
• DFG-out 33%
• Polar Residues 33%

Biochemistry, Genetics and Molecular Biology

• Protein Kinases 100%
• Aurora A Kinase 100%
• Infrared Radiation 50%
• Active Site 50%
• Conformational Change 50%
• Hydrogen Bond 50%
• Enzymatic Activity 50%
• Energy Transfer 50%