A Very Rare Case of Sarcoid-Lymphoma Syndrome Imposing an Intriguing Diagnostic Challenge

Aiham H. Jbeli, Ashwyna Sunassee, Amy Sanford, Ashraf Elshami, Jonathan Bleeker

Research output: Contribution to journalArticlepeer-review


An enigmatic association between sarcoidosis and lymphoma has been proposed in the past. This poses a significant diagnostic challenge, especially when the time interval is less than one year between the two diagnoses. A 54-year-old male patient presented to his primary care physician with worsening acute kidney injury and hypercalcemia. His chest x-ray showed bilateral interstitial nodular thickening and mild bilateral hilar fullness. After a diagnostic workup, the patient was diagnosed with sarcoidosis and started on prednisone. He initially improved, but returned with acute kidney injury, hypercalcemia, and generalized lymphadenopathy. An excisional lymph node biopsy was positive for diffuse large B-cell lymphoma. Our case illustrates the sarcoidosis-lymphoma syndrome. Although there is no recommendation to screen patients with sarcoidosis for malignancy, it is crucial to be aware of this association and to evaluate any new or enlarging lymphadenopathy with a biopsy. It is essential to assess response to prednisone in patients with sarcoidosis.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalSouth Dakota medicine : the journal of the South Dakota State Medical Association
Issue number3
StatePublished - Mar 1 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright© South Dakota State Medical Association.


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