A valid and reliable measure of constipation-related quality of life

Jennifer Y. Wang, Stacey L. Hart, Janet Lee, Julia R. Berian, G. Lindsay McCrea, Madhulika G. Varma

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


PURPOSE: Few existing measures assess constipationspecific quality of life. This study sought to develop a valid and reliable quality-of-life measure for constipation. METHODS: First, we created a preliminary instrument that assessed quality-of-life domains affected by constipation: body image, eating, mood, and relationships with others. We conducted focus groups both with patients with constipation seeking treatment and the health care providers who treat them. Next, a 59-item questionnaire was given to 240 subjects with constipation (83% female) and 103 healthy volunteers (63% female). Test-retest reliability and discriminant, convergent, and divergent validity were assessed. RESULTS: Exploratory factor analysis revealed four domains: Social Impairment (five items), Distress (six items), Eating Habits (three items), and Bathroom Attitudes (four items). Internal consistency and testretest reliability for all subscales was high (Cronbach's alpha = 0.89; intraclass correlation coefficient = 0.87). All domains discriminated well between subjects with constipation and healthy volunteers (P < 0.001). Convergent validity was excellent: all subscales correlated highly with the Irritable Bowel Syndrome Quality of Life Scale total score (P < 0.001) and the Medical Outcomes Study Short Form-36 physical component and mental component summary scores (P < 0.001). Scores from our Constipation-Related Quality of Life measure were not significantly correlated with the Social Desirability Scale, demonstrating divergent validity. CONCLUSIONS: Our findings support the reliability and validity of the Constipation-Related Quality of Life measure. Future validation of the Constipation-Related Quality of Life measure for assessing changes in quality of life in response to treatments for constipation is needed.

Original languageEnglish (US)
Pages (from-to)1434-1442
Number of pages9
JournalDiseases of the colon and rectum
Issue number8
StatePublished - Aug 2009
Externally publishedYes


  • Bowel questionnaire
  • Constipation
  • Quality-of-life measure
  • Validation study


Dive into the research topics of 'A valid and reliable measure of constipation-related quality of life'. Together they form a unique fingerprint.

Cite this