TY - JOUR
T1 - A unique pattern of extranodal involvement in Korean adults with sporadic Burkitt lymphoma
T2 - A single center experience
AU - Jang, Sun Joo
AU - Hyun Yoon, Dok
AU - Kim, Shin
AU - Yoon, Shinkyo
AU - Kim, Dal Yong
AU - Park, Chan Sik
AU - Huh, Jooryung
AU - Lee, Sang Wook
AU - Lee, Dae Ho
AU - Ryu, Jin Sook
AU - Suh, Cheolwon
PY - 2012/12
Y1 - 2012/12
N2 - Extranodal involvement is common in patients with Burkitt lymphoma (BL). We evaluated the pattern of extranodal involvement and its impact on clinical outcomes in a single center cohort of adult Korean patients with sporadic BL. We retrospectively identified 64 patients with BL in the registry of non-Hodgkin lymphoma of the Asan Medical Center between 1996 and 2009. We assessed their clinical features and distribution of extranodal sites and analyzed clinical outcomes, including complete response rate after chemotherapy, overall survival, and progressionfree survival, relative to baseline characteristics and involved extranodal sites. Extranodal involvement was found in 57 patients (89 %), with 34 (53.1 %) having two or more extranodal sites. The stomach (26.6 %) was the most common site, followed by the small and large intestines (25 %), bone marrow (23.4 %), genitourinary tract (21.9 %), and bones (18.8 %). Two patients (3.1 %) showed central nervous system (CNS) involvement. Complete response rates to chemotherapy were not related to sites of extranodal involvement. Two-year overall survival rates were lower in patients with bone marrow (33.3 vs. 74.6 %, p=0.010) and CNS (0.0 vs. 66.6 %, p=0.048) involvement than in patients with involvement at other extranodal sites. The stomach, genitourinary tract, and bones were the most commonly involved extranodal sites in Korean BL patients, but site had no prognostic significance
AB - Extranodal involvement is common in patients with Burkitt lymphoma (BL). We evaluated the pattern of extranodal involvement and its impact on clinical outcomes in a single center cohort of adult Korean patients with sporadic BL. We retrospectively identified 64 patients with BL in the registry of non-Hodgkin lymphoma of the Asan Medical Center between 1996 and 2009. We assessed their clinical features and distribution of extranodal sites and analyzed clinical outcomes, including complete response rate after chemotherapy, overall survival, and progressionfree survival, relative to baseline characteristics and involved extranodal sites. Extranodal involvement was found in 57 patients (89 %), with 34 (53.1 %) having two or more extranodal sites. The stomach (26.6 %) was the most common site, followed by the small and large intestines (25 %), bone marrow (23.4 %), genitourinary tract (21.9 %), and bones (18.8 %). Two patients (3.1 %) showed central nervous system (CNS) involvement. Complete response rates to chemotherapy were not related to sites of extranodal involvement. Two-year overall survival rates were lower in patients with bone marrow (33.3 vs. 74.6 %, p=0.010) and CNS (0.0 vs. 66.6 %, p=0.048) involvement than in patients with involvement at other extranodal sites. The stomach, genitourinary tract, and bones were the most commonly involved extranodal sites in Korean BL patients, but site had no prognostic significance
KW - Burkitt lymphoma
KW - Extranodal lymphoma
KW - Non-Hodgkin's lymphoma
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=84871024830&partnerID=8YFLogxK
U2 - 10.1007/s00277-012-1531-1
DO - 10.1007/s00277-012-1531-1
M3 - Article
C2 - 22864762
AN - SCOPUS:84871024830
SN - 0939-5555
VL - 91
SP - 1917
EP - 1922
JO - Annals of Hematology
JF - Annals of Hematology
IS - 12
ER -
