A unified taxonomy for ciliary dyneins

Erik F.Y. Hom, George B. Witman, Elizabeth H. Harris, Susan K. Dutcher, Ritsu Kamiya, David R. Mitchell, Gregory J. Pazour, Mary E. Porter, Winfield S. Sale, Maureen Wirschell, Toshiki Yagi, Stephen M. King

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The formation and function of eukaryotic cilia/flagella require the action of a large array of dynein microtubule motor complexes. Due to genetic, biochemical, and microscopic tractability, Chlamydomonas reinhardtii has become the premier model system in which to dissect the role of dyneins in flagellar assembly, motility, and signaling. Currently, 54 proteins have been described as components of various Chlamydomonas flagellar dyneins or as factors required for their assembly in the cytoplasm and/or transport into the flagellum; orthologs of nearly all these components are present in other ciliated organisms including humans. For historical reasons, the nomenclature of these diverse dynein components and their corresponding genes, mutant alleles, and orthologs has become extraordinarily confusing. Here, we unify Chlamydomonas dynein gene nomenclature and establish a systematic classification scheme based on structural properties of the encoded proteins. Furthermore, we provide detailed tabulations of the various mutant alleles and protein aliases that have been used and explicitly define the correspondence with orthologous components in other model organisms and humans.

Original languageEnglish (US)
Pages (from-to)555-565
Number of pages11
JournalCytoskeleton
Volume68
Issue number10
DOIs
StatePublished - Oct 1 2011

Fingerprint

Dyneins
Chlamydomonas
Flagella
Terminology
Alleles
Chlamydomonas reinhardtii
Cilia
Mutant Proteins
Microtubules
Genes
Molecular Biology
Cytoplasm
Proteins

Keywords

  • Chlamydomonas
  • Cilia
  • Dynein
  • Flagella
  • Microtubule

Cite this

Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., ... King, S. M. (2011). A unified taxonomy for ciliary dyneins. Cytoskeleton, 68(10), 555-565. https://doi.org/10.1002/cm.20533

A unified taxonomy for ciliary dyneins. / Hom, Erik F.Y.; Witman, George B.; Harris, Elizabeth H.; Dutcher, Susan K.; Kamiya, Ritsu; Mitchell, David R.; Pazour, Gregory J.; Porter, Mary E.; Sale, Winfield S.; Wirschell, Maureen; Yagi, Toshiki; King, Stephen M.

In: Cytoskeleton, Vol. 68, No. 10, 01.10.2011, p. 555-565.

Research output: Contribution to journalArticle

Hom, EFY, Witman, GB, Harris, EH, Dutcher, SK, Kamiya, R, Mitchell, DR, Pazour, GJ, Porter, ME, Sale, WS, Wirschell, M, Yagi, T & King, SM 2011, 'A unified taxonomy for ciliary dyneins', Cytoskeleton, vol. 68, no. 10, pp. 555-565. https://doi.org/10.1002/cm.20533
Hom EFY, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR et al. A unified taxonomy for ciliary dyneins. Cytoskeleton. 2011 Oct 1;68(10):555-565. https://doi.org/10.1002/cm.20533
Hom, Erik F.Y. ; Witman, George B. ; Harris, Elizabeth H. ; Dutcher, Susan K. ; Kamiya, Ritsu ; Mitchell, David R. ; Pazour, Gregory J. ; Porter, Mary E. ; Sale, Winfield S. ; Wirschell, Maureen ; Yagi, Toshiki ; King, Stephen M. / A unified taxonomy for ciliary dyneins. In: Cytoskeleton. 2011 ; Vol. 68, No. 10. pp. 555-565.
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