A Trojan Horse mechanism for the spread of visna virus in monocytes

Richard Peluso; Ashley Haase; Linda Stowring; Mike Edwards; Peter Ventura

doi:10.1016/0042-6822(85)90246-6

A Trojan Horse mechanism for the spread of visna virus in monocytes

Richard Peluso, Ashley Haase, Linda Stowring, Mike Edwards, Peter Ventura

Microbiology

Research output: Contribution to journal › Article › peer-review

290 Scopus citations

Abstract

Visna virus is the prototype of the lentivirus subfamily of retroviruses that cause slow infections of sheep and goats. These viruses persist and can be isolated from blood and cerebrospinal fluid for years despite neutralizing antibody. In the studies reported here we have used quantitative in situ hybridization to analyze infected leukocytes. We show that (1) monocytes harbor the visna genome; and (2) virus gene expression is as constrained in this cell as it is in glial and epithelial cells. These results are in accord with a Trojan Horse mechanism of virus dissemination in an immunologically responsive host.

Original language	English (US)
Pages (from-to)	231-236
Number of pages	6
Journal	Virology
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(85)90246-6
State	Published - Nov 1985

Bibliographical note

Funding Information:
We thank Colleen O’Neill and Jan Torma for typing the manuscript. This work was supported by the National Institutes of Health and American Cancer Society, and by institutional support mechanisms of the Veterans Administration. During the course of this work, Dr. Ashley Haase was a medical investigator at the Veterans Administration.

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title = "A Trojan Horse mechanism for the spread of visna virus in monocytes",

abstract = "Visna virus is the prototype of the lentivirus subfamily of retroviruses that cause slow infections of sheep and goats. These viruses persist and can be isolated from blood and cerebrospinal fluid for years despite neutralizing antibody. In the studies reported here we have used quantitative in situ hybridization to analyze infected leukocytes. We show that (1) monocytes harbor the visna genome; and (2) virus gene expression is as constrained in this cell as it is in glial and epithelial cells. These results are in accord with a Trojan Horse mechanism of virus dissemination in an immunologically responsive host.",

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AU - Peluso, Richard

AU - Haase, Ashley

AU - Stowring, Linda

AU - Edwards, Mike

AU - Ventura, Peter

N1 - Funding Information: We thank Colleen O’Neill and Jan Torma for typing the manuscript. This work was supported by the National Institutes of Health and American Cancer Society, and by institutional support mechanisms of the Veterans Administration. During the course of this work, Dr. Ashley Haase was a medical investigator at the Veterans Administration.

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N2 - Visna virus is the prototype of the lentivirus subfamily of retroviruses that cause slow infections of sheep and goats. These viruses persist and can be isolated from blood and cerebrospinal fluid for years despite neutralizing antibody. In the studies reported here we have used quantitative in situ hybridization to analyze infected leukocytes. We show that (1) monocytes harbor the visna genome; and (2) virus gene expression is as constrained in this cell as it is in glial and epithelial cells. These results are in accord with a Trojan Horse mechanism of virus dissemination in an immunologically responsive host.

AB - Visna virus is the prototype of the lentivirus subfamily of retroviruses that cause slow infections of sheep and goats. These viruses persist and can be isolated from blood and cerebrospinal fluid for years despite neutralizing antibody. In the studies reported here we have used quantitative in situ hybridization to analyze infected leukocytes. We show that (1) monocytes harbor the visna genome; and (2) virus gene expression is as constrained in this cell as it is in glial and epithelial cells. These results are in accord with a Trojan Horse mechanism of virus dissemination in an immunologically responsive host.

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A Trojan Horse mechanism for the spread of visna virus in monocytes

Abstract

Bibliographical note

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