A transcriptome dataset for gonadectomy-induced changes in rat spinal cord

Shawn Miller, Juan E. Abrahante, Avtar Roopra, Brendan J. Dougherty

Research output: Contribution to journalArticlepeer-review

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Circulating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits; less is known regarding hormonal influence of ventral spinal motor function. Gonadectomy (surgical removal of the testes in males and ovaries in females) rapidly and persistently reduces circulating sex steroids in both females and males, providing a means to interrogate the role of hormones on neural function. Here we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the impact of gonadectomy on the transcriptome of ventral spinal cord tissue of adult female and male rats.

Original languageEnglish (US)
Article number789
JournalScientific Data
Issue number1
StatePublished - Dec 2022

Bibliographical note

Funding Information:
The authors would like to acknowledge the contribution of the UMN Genomics Center, in particular, John Garbe, Veronica Tonnell, and Elyse Froehling. This work was supported by funding from the NIH National Heart, Lung, and Blood Institute (R01HL146477-01A1), The Craig H. Neilsen Foundation, and the University of Minnesota Division of Physical Therapy. Figure one was created using Biorender.com.

Publisher Copyright:
© 2022, The Author(s).


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