A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients

D. Belsito, D. Bickers, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, H. Greim, Y. Miyachi, J. H. Saurat, I. G. Sipes

    Research output: Contribution to journalReview article

    44 Citations (Scopus)

    Abstract

    The cyclopentanone and cyclopentenone group of fragrance ingredients was critically evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.002% to 15.16% in hydroalcoholic products; systemic exposures vary from 0.0003 to 0.7122. mg/kg/day. The cyclopentanones and cyclopentenones had a low order of acute toxicity and no significant toxicity in repeat dose studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. Developmental toxicity was not observed. Minimal evidence of skin irritation in humans is associated with current levels of use. Eleven materials were tested undiluted for eye irritation; three were considered irritants. No phototoxic and photosensitization reactions were seen with nine materials tested. At concentrations higher than current reported use, 14 materials were non-sensitizing in HRIPT or maximization tests. 2-Hexylidene cyclopentanone, 2-heptylidenecyclopentan-1-one and 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one are weak sensitizers and have IFRA Standards. Risk of sensitization to the cyclopentanones and cyclopentenones is generally small under current levels of use. The Panel is of the opinion that there are no safety concerns for the cyclopentanones and cyclopentenones at reported levels of use and exposure as fragrance ingredients.

    Original languageEnglish (US)
    JournalFood and Chemical Toxicology
    Volume50
    Issue numberSUPPL.3
    DOIs
    StatePublished - Oct 1 2012

    Fingerprint

    Fragrances
    ingredients
    odors
    Toxicity
    dermal exposure
    eye irritation
    developmental toxicity
    skin irritation
    acute toxicity
    Photosensitivity Disorders
    Safety
    Skin
    cell lines
    Irritants
    toxicity
    bacteria
    assays
    dosage
    Assays
    Bacteria

    Keywords

    • Cyclopentanones
    • Cyclopentenones
    • Fragrance material
    • Group summary
    • Ketones
    • Review

    Cite this

    A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients. / Belsito, D.; Bickers, D.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Greim, H.; Miyachi, Y.; Saurat, J. H.; Sipes, I. G.

    In: Food and Chemical Toxicology, Vol. 50, No. SUPPL.3, 01.10.2012.

    Research output: Contribution to journalReview article

    Belsito, D, Bickers, D, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Greim, H, Miyachi, Y, Saurat, JH & Sipes, IG 2012, 'A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients', Food and Chemical Toxicology, vol. 50, no. SUPPL.3. https://doi.org/10.1016/j.fct.2012.04.019
    Belsito, D. ; Bickers, D. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Greim, H. ; Miyachi, Y. ; Saurat, J. H. ; Sipes, I. G. / A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients. In: Food and Chemical Toxicology. 2012 ; Vol. 50, No. SUPPL.3.
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    AU - Calow, P.

    AU - Dagli, M. L.

    AU - Dekant, W.

    AU - Fryer, A. D.

    AU - Greim, H.

    AU - Miyachi, Y.

    AU - Saurat, J. H.

    AU - Sipes, I. G.

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