A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients

D. Belsito, D. Bickers, M. Bruze, P. Calow, M. Dagli, A. D. Fryer, H. Greim, Y. Miyachi, J. H. Saurat, I. G. Sipes

    Research output: Contribution to journalReview article

    7 Citations (Scopus)

    Abstract

    The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280. mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in petrolatum. The cinnamyl phenylpropyl materials had low acute toxicity and no significant toxicity in repeat dose oral or dermal toxicity studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. The cinnamyl phenylpropyl alcohol materials participate in the same beta oxidation pathways as their parent cinnamic acid derivatives, including common routes of absorption, distribution, and metabolic detoxification, and exhibit similar toxicological endpoints. Based on the review of available data, it is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients.

    Original languageEnglish (US)
    JournalFood and Chemical Toxicology
    Volume49
    Issue numberSUPPL. 2
    DOIs
    StatePublished - Dec 1 2011

    Fingerprint

    Fragrances
    Toxicology
    ingredients
    odors
    Toxicity
    Petrolatum
    Skin
    Metabolome
    Irritants
    Aldehydes
    Esters
    Alcohols
    Bacteria
    Safety
    Cell Line
    alcohols
    petrolatum
    metabolic detoxification
    dermal exposure
    toxicity

    Keywords

    • Cinnamyl phenylpropyl
    • Fragrance ingredients
    • Review
    • Safety

    Cite this

    A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients. / Belsito, D.; Bickers, D.; Bruze, M.; Calow, P.; Dagli, M.; Fryer, A. D.; Greim, H.; Miyachi, Y.; Saurat, J. H.; Sipes, I. G.

    In: Food and Chemical Toxicology, Vol. 49, No. SUPPL. 2, 01.12.2011.

    Research output: Contribution to journalReview article

    Belsito, D, Bickers, D, Bruze, M, Calow, P, Dagli, M, Fryer, AD, Greim, H, Miyachi, Y, Saurat, JH & Sipes, IG 2011, 'A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients', Food and Chemical Toxicology, vol. 49, no. SUPPL. 2. https://doi.org/10.1016/j.fct.2011.07.053
    Belsito, D. ; Bickers, D. ; Bruze, M. ; Calow, P. ; Dagli, M. ; Fryer, A. D. ; Greim, H. ; Miyachi, Y. ; Saurat, J. H. ; Sipes, I. G. / A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients. In: Food and Chemical Toxicology. 2011 ; Vol. 49, No. SUPPL. 2.
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