A titanic drug resistance threat in Cryptococcus neoformans

Hanna Zafar, Sophie Altamirano, Elizabeth R. Ballou, Kirsten Nielsen

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalCurrent Opinion in Microbiology
Volume52
DOIs
StatePublished - Dec 2019

Bibliographical note

Funding Information:
HZ is supported by an NC3Rs PhD studentship (NC/R001472/1). DSA is a TREM post-doctoral fellow supported by U.S. National Institutes of Health grant K12GM119955. ERB is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (211241/Z/18/Z). KN is supported by U.S. National Institutes of Health grant R01AI134636.

Funding Information:
HZ is supported by an NC3Rs PhD studentship ( NC/R001472/1 ). DSA is a TREM post-doctoral fellow supported by U.S. National Institutes of Health grant K12GM119955 . ERB is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society ( 211241/Z/18/Z ). KN is supported by U.S. National Institutes of Health grant R01AI134636 .

Publisher Copyright:
© 2019 Elsevier Ltd

Fingerprint

Dive into the research topics of 'A titanic drug resistance threat in Cryptococcus neoformans'. Together they form a unique fingerprint.

Cite this