A titanic drug resistance threat in Cryptococcus neoformans

Hanna Zafar, Sophie Altamirano, Elizabeth R. Ballou, Kirsten Nielsen

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalCurrent Opinion in Microbiology
Volume52
DOIs
StatePublished - Dec 2019

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PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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