A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Melanie S. Vacchio, Thomas Ciucci, Yayi Gao, Masashi Watanabe, Mariah Balmaceno-Criss, Mitchell T. McGinty, Allan Huang, Qi Xiao, Cameron McConkey, Yongmei Zhao, Jyoti Shetty, Bao Tran, Marion Pepper, Golnaz Vahedi, Marc K. Jenkins, Dorian B. McGavern, Rémy Bosselut

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The transcription factor Thpok is essential for the development of CD4+ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4+ T cells into T follicular helper (Tfh) cells, thus linking the CD4+ lineage to Tfh cell differentiation.

Original languageEnglish (US)
Pages (from-to)465-478.e6
JournalImmunity
Volume51
Issue number3
DOIs
StatePublished - Sep 17 2019

Bibliographical note

Funding Information:
We thank T.-A. Lewis, E. Castro, and H. Kwak for expert animal care and genotyping; Y. Belkaid, J. Zhu, J. O’Shea, Ming Li, R. Ahmed, and the NIH tetramer facility for mice and reagents; Maggie Cam (CCR Bioinformatics Core), the CCR Flow Cytometry Core, the CCR Confocal Microscopy Core Facility, and the NIH high-performance computing cluster for assistance; and J. Ashwell, Y. Belkaid, R. Hodes, P. Love, and J. Zhu for reading the manuscript. This work benefited from data assembled by the Immgen Consortium. Supported by the Intramural Research Program of the National Cancer Institute, Center for Cancer Research, NIH .

Publisher Copyright:
© 2019

Keywords

  • Bcl6
  • CD4 T cells
  • Maf
  • Thpok
  • follicular helper T cells
  • germinal center reaction

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