A thin-walled carotid vessel phantom for Doppler ultrasound flow studies

Tamie L. Poepping; Hristo N. Nikolov; Meghan L. Thorne; David W. Holdsworth

doi:10.1016/j.ultrasmedbio.2004.06.003

A thin-walled carotid vessel phantom for Doppler ultrasound flow studies

Tamie L. Poepping, Hristo N. Nikolov, Meghan L. Thorne, David W. Holdsworth

Earl E. Bakken Medical Device Center

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

A technique is discussed for producing a robust ultrasound (US)-compatible flow phantom that consists of a thin-walled silicone-elastomer vessel with a lumen of arbitrary geometry, embedded in an agar-based tissue-mimicking material (TMM). The TMM has an acoustic attenuation of 0.56 dB cm^-1 MHz ^-1 at 5 MHz, with nearly linear frequency-dependence and acoustic velocity of 1539 ± 4 m s^-1. The vessel-mimicking material (VMM) has an acoustic attenuation of 3.5 dB cm^-1 MHz^-1 with linear frequency-dependence and an acoustic velocity of 1020 ± 20 m s^-1. Scattering particles, which are added to the VMM to increase echogenicity and add speckle texture, lead to higher attenuation, depending on particle concentration and frequency. The VMM is stable over time, with a Young's elastic modulus of 1.3 to 1.7 MPa for strains of up to 10%, which mimics human arteries under typical physiological conditions. The phantom is sealed to prevent TMM exposure to air or water, to avoid changes to the acoustic velocity.

Original language	English (US)
Pages (from-to)	1067-1078
Number of pages	12
Journal	Ultrasound in Medicine and Biology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2004.06.003
State	Published - Aug 2004

Bibliographical note

Funding Information:
The authors acknowledge Andrew Hui for his assistance with the material stress testing, Chris Blake and Sue Soney for their assistance with the 3-D ultrasound scans, Dr. Paul Picot for his advice on acoustic property measurements and ATL (Advanced Technology Laboratories, Philips, Seattle, WA) for the HDI 5000 ultrasound unit. Financial support has been provided by the Heart and Stroke Foundation of Canada (grant #T-5135 and research scholarship of D.W. Holdsworth), in conjunction with the Canadian Institutes of Health Research (group grant #GR-14973 and CIHR/HSFC partnership graduate scholarship of T.L. Poepping), and the Robarts Research Institute (graduate student award of T.L. Poepping). D.W. Holdsworth is a Career Investigator, supported by the Heart and Stroke Foundation of Ontario.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Acoustic attenuation
Acoustic velocity
Carotid artery bifurcation
Doppler ultrasound
Elastic modulus
Flow phantom
Silicone elastomer
Speed of sound
Sylgard 184
Tissue-mimicking material
Vessel-mimicking material

Publisher link

10.1016/j.ultrasmedbio.2004.06.003

Find It

Find It at U of M Libraries

Cite this

@article{ddaa106800d742da8b4c5358e390ee58,

title = "A thin-walled carotid vessel phantom for Doppler ultrasound flow studies",

abstract = "A technique is discussed for producing a robust ultrasound (US)-compatible flow phantom that consists of a thin-walled silicone-elastomer vessel with a lumen of arbitrary geometry, embedded in an agar-based tissue-mimicking material (TMM). The TMM has an acoustic attenuation of 0.56 dB cm-1 MHz -1 at 5 MHz, with nearly linear frequency-dependence and acoustic velocity of 1539 ± 4 m s-1. The vessel-mimicking material (VMM) has an acoustic attenuation of 3.5 dB cm-1 MHz-1 with linear frequency-dependence and an acoustic velocity of 1020 ± 20 m s-1. Scattering particles, which are added to the VMM to increase echogenicity and add speckle texture, lead to higher attenuation, depending on particle concentration and frequency. The VMM is stable over time, with a Young's elastic modulus of 1.3 to 1.7 MPa for strains of up to 10%, which mimics human arteries under typical physiological conditions. The phantom is sealed to prevent TMM exposure to air or water, to avoid changes to the acoustic velocity.",

keywords = "Acoustic attenuation, Acoustic velocity, Carotid artery bifurcation, Doppler ultrasound, Elastic modulus, Flow phantom, Silicone elastomer, Speed of sound, Sylgard 184, Tissue-mimicking material, Vessel-mimicking material",

author = "Poepping, {Tamie L.} and Nikolov, {Hristo N.} and Thorne, {Meghan L.} and Holdsworth, {David W.}",

note = "Funding Information: The authors acknowledge Andrew Hui for his assistance with the material stress testing, Chris Blake and Sue Soney for their assistance with the 3-D ultrasound scans, Dr. Paul Picot for his advice on acoustic property measurements and ATL (Advanced Technology Laboratories, Philips, Seattle, WA) for the HDI 5000 ultrasound unit. Financial support has been provided by the Heart and Stroke Foundation of Canada (grant #T-5135 and research scholarship of D.W. Holdsworth), in conjunction with the Canadian Institutes of Health Research (group grant #GR-14973 and CIHR/HSFC partnership graduate scholarship of T.L. Poepping), and the Robarts Research Institute (graduate student award of T.L. Poepping). D.W. Holdsworth is a Career Investigator, supported by the Heart and Stroke Foundation of Ontario. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2004",

month = aug,

doi = "10.1016/j.ultrasmedbio.2004.06.003",

language = "English (US)",

volume = "30",

pages = "1067--1078",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier USA",

number = "8",

}

TY - JOUR

T1 - A thin-walled carotid vessel phantom for Doppler ultrasound flow studies

AU - Poepping, Tamie L.

AU - Nikolov, Hristo N.

AU - Thorne, Meghan L.

AU - Holdsworth, David W.

N1 - Funding Information: The authors acknowledge Andrew Hui for his assistance with the material stress testing, Chris Blake and Sue Soney for their assistance with the 3-D ultrasound scans, Dr. Paul Picot for his advice on acoustic property measurements and ATL (Advanced Technology Laboratories, Philips, Seattle, WA) for the HDI 5000 ultrasound unit. Financial support has been provided by the Heart and Stroke Foundation of Canada (grant #T-5135 and research scholarship of D.W. Holdsworth), in conjunction with the Canadian Institutes of Health Research (group grant #GR-14973 and CIHR/HSFC partnership graduate scholarship of T.L. Poepping), and the Robarts Research Institute (graduate student award of T.L. Poepping). D.W. Holdsworth is a Career Investigator, supported by the Heart and Stroke Foundation of Ontario. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004/8

Y1 - 2004/8

N2 - A technique is discussed for producing a robust ultrasound (US)-compatible flow phantom that consists of a thin-walled silicone-elastomer vessel with a lumen of arbitrary geometry, embedded in an agar-based tissue-mimicking material (TMM). The TMM has an acoustic attenuation of 0.56 dB cm-1 MHz -1 at 5 MHz, with nearly linear frequency-dependence and acoustic velocity of 1539 ± 4 m s-1. The vessel-mimicking material (VMM) has an acoustic attenuation of 3.5 dB cm-1 MHz-1 with linear frequency-dependence and an acoustic velocity of 1020 ± 20 m s-1. Scattering particles, which are added to the VMM to increase echogenicity and add speckle texture, lead to higher attenuation, depending on particle concentration and frequency. The VMM is stable over time, with a Young's elastic modulus of 1.3 to 1.7 MPa for strains of up to 10%, which mimics human arteries under typical physiological conditions. The phantom is sealed to prevent TMM exposure to air or water, to avoid changes to the acoustic velocity.

AB - A technique is discussed for producing a robust ultrasound (US)-compatible flow phantom that consists of a thin-walled silicone-elastomer vessel with a lumen of arbitrary geometry, embedded in an agar-based tissue-mimicking material (TMM). The TMM has an acoustic attenuation of 0.56 dB cm-1 MHz -1 at 5 MHz, with nearly linear frequency-dependence and acoustic velocity of 1539 ± 4 m s-1. The vessel-mimicking material (VMM) has an acoustic attenuation of 3.5 dB cm-1 MHz-1 with linear frequency-dependence and an acoustic velocity of 1020 ± 20 m s-1. Scattering particles, which are added to the VMM to increase echogenicity and add speckle texture, lead to higher attenuation, depending on particle concentration and frequency. The VMM is stable over time, with a Young's elastic modulus of 1.3 to 1.7 MPa for strains of up to 10%, which mimics human arteries under typical physiological conditions. The phantom is sealed to prevent TMM exposure to air or water, to avoid changes to the acoustic velocity.

KW - Acoustic attenuation

KW - Acoustic velocity

KW - Carotid artery bifurcation

KW - Doppler ultrasound

KW - Elastic modulus

KW - Flow phantom

KW - Silicone elastomer

KW - Speed of sound

KW - Sylgard 184

KW - Tissue-mimicking material

KW - Vessel-mimicking material

UR - http://www.scopus.com/inward/record.url?scp=4944253451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4944253451&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2004.06.003

DO - 10.1016/j.ultrasmedbio.2004.06.003

M3 - Article

C2 - 15474751

AN - SCOPUS:4944253451

SN - 0301-5629

VL - 30

SP - 1067

EP - 1078

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 8

ER -

A thin-walled carotid vessel phantom for Doppler ultrasound flow studies

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this