A thermostable transketolase evolved for aliphatic aldehyde acceptors

Dong Yi, Thangavelu Saravanan, Titu Devamani, Franck Charmantray, Laurence Hecquet, Wolf Dieter Fessner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Directed evolution of the thermostable transketolase from Geobacillus stearothermophilus based on a pH-based colorimetric screening of smart libraries yielded several mutants with up to 16-fold higher activity for aliphatic aldehydes and high enantioselectivity (>95% ee) in the asymmetric carboligation step. This journal is

Original languageEnglish (US)
Pages (from-to)480-483
Number of pages4
JournalChemical Communications
Volume51
Issue number3
DOIs
StatePublished - Jan 11 2015

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