A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone

Markus Meyer; Martin M. Lewinter; Michael R. Zile

doi:10.1161/CIRCULATIONAHA.121.056412

A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone

Markus Meyer, Martin M. Lewinter, Michael R. Zile

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

PDE3 inhibition and pacing result in an increase in Ca2+- dependent myofilament activation resulting in a leftward movement of the pressure-volume loop and smaller LV volumes. Thus, the ventricle begins to fill at a smaller volume and spends more of its filling on the flatter, nonexponential segment of the diastolic PVR, whereas a prolongation of diastole with heart rate–lowering drugs may do the opposite.

Original language	English (US)
Pages (from-to)	1269-1271
Number of pages	3
Journal	Circulation
Volume	144
Issue number	16
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.121.056412
State	Published - Oct 19 2021

Bibliographical note

Funding Information:
Dr Meyer was supported by grant R01 HL-122744 from the National Institutes of Health.

Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.

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10.1161/CIRCULATIONAHA.121.056412

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abstract = "PDE3 inhibition and pacing result in an increase in Ca2+- dependent myofilament activation resulting in a leftward movement of the pressure-volume loop and smaller LV volumes. Thus, the ventricle begins to fill at a smaller volume and spends more of its filling on the flatter, nonexponential segment of the diastolic PVR, whereas a prolongation of diastole with heart rate–lowering drugs may do the opposite.",

author = "Markus Meyer and Lewinter, {Martin M.} and Zile, {Michael R.}",

note = "Funding Information: Dr Meyer was supported by grant R01 HL-122744 from the National Institutes of Health. Publisher Copyright: {\textcopyright} 2021 Lippincott Williams and Wilkins. All rights reserved.",

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doi = "10.1161/CIRCULATIONAHA.121.056412",

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T2 - Taking Advantage of Diastolic Tone

AU - Meyer, Markus

AU - Lewinter, Martin M.

AU - Zile, Michael R.

PY - 2021/10/19

Y1 - 2021/10/19

N2 - PDE3 inhibition and pacing result in an increase in Ca2+- dependent myofilament activation resulting in a leftward movement of the pressure-volume loop and smaller LV volumes. Thus, the ventricle begins to fill at a smaller volume and spends more of its filling on the flatter, nonexponential segment of the diastolic PVR, whereas a prolongation of diastole with heart rate–lowering drugs may do the opposite.

AB - PDE3 inhibition and pacing result in an increase in Ca2+- dependent myofilament activation resulting in a leftward movement of the pressure-volume loop and smaller LV volumes. Thus, the ventricle begins to fill at a smaller volume and spends more of its filling on the flatter, nonexponential segment of the diastolic PVR, whereas a prolongation of diastole with heart rate–lowering drugs may do the opposite.

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ER -

A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone

Abstract

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