A systematic review of dental late effects in survivors of childhood cancer

Prasad L. Gawade, Melissa M. Hudson, Sue C. Kaste, Joseph P. Neglia, Louis S. Constine, Leslie L. Robison, Kirsten K. Ness

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Survivors of childhood cancer are at risk for dental late effects. This systematic review summarizes associations between treatment exposures and dental late effects among survivors of childhood cancer. We included investigations with at least 20 study participants conducted for 2 or more years after completion of childhood, adolescent, or young adult cancer therapy. This review suggests both independent and additive effects of radiotherapy and chemotherapy on dental complications, and identifies vulnerable groups with specific host and treatment characteristics. This summary provides information that will assist clinicians to prevent, detect, and facilitate early intervention for dental late effects.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalPediatric Blood and Cancer
Issue number3
StatePublished - Mar 2014


  • Chemotherapy
  • Pediatrics
  • Radiotherapy
  • Tooth abnormalities


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