A systematic evaluation of poloxamers as tablet lubricants

Jiangnan Dun, Frederick Osei-Yeboah, Pierre Boulas, Yiqing Lin, Changquan Calvin Sun

Research output: Contribution to journalArticle

Abstract

Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution. In this study, we have systematically evaluated two poloxamers, P188 and P407, for their suitability as alternative tablet lubricants. For two excipients with different mechanical properties, i.e., microcrystalline cellulose and lactose, both poloxamers exhibit acceptable lubrication efficiency without negatively impacting tabletability. Compared to 1% MgSt, the performance of 2% of both poloxamers in an experimental tablet formulation of ritonavir led to better lubrication, higher tabletability, and enhanced in vitro drug release. Thus, the use of P188 and P407 as alternative tablet lubricants deserves further evaluations.

Original languageEnglish (US)
Article number118994
JournalInternational journal of pharmaceutics
Volume576
DOIs
StatePublished - Feb 25 2020

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Keywords

  • Dissolution
  • Formulation
  • Lubrication
  • Magnesium stearate
  • Poloxamer
  • Tabletability

PubMed: MeSH publication types

  • Journal Article

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