A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer

Jiangnan Dun, Frederick Osei-Yeboah, Pierre Boulas, Yiqing Lin, Calvin Sun

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Appropriate lubrication is important in tablet manufacturing as it lowers punch sticking propensity and protects tooling by reducing friction between die wall and tablet during tablet manufacturing. Most commercial lubricants negatively impact tabletability and dissolution. A delicate balance is usually attained by trial and error to identify the optimal level of lubricant in a tablet formulation. In this work, we have evaluated the effectiveness of sodium lauryl sulfate (SLS), a surfactant, as a tableting lubricant. If adequate lubrication efficiency is achieved, the use of SLS may be suitable to mitigate problems associated with hydrophobic lubricants. Results show that SLS, when applied in the proper amount to typical pharmaceutical powder mixtures, achieved lubrication efficiency comparable to a grade of magnesium stearate (MgSt) without deteriorating tabletability. Moreover, SLS-containing tablets of celecoxib also exhibited improved in vitro dissolution compared to MgSt-containing tablets. The enhancement in dissolution properties was attributed to the improved wetting by the dissolution medium due to the presence of SLS.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalInternational journal of pharmaceutics
Volume552
Issue number1-2
DOIs
StatePublished - Dec 1 2018

Keywords

  • Dissolution
  • Ejection force
  • Lubrication
  • Magnesium stearate
  • Sodium lauryl sulfate
  • Tabletability

Fingerprint Dive into the research topics of 'A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and wetting enhancer'. Together they form a unique fingerprint.

Cite this