A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Naga Kiran Duggirala; Jinghan Li; N. S. Krishna Kumar; Gopinath Tata; Raj Suryanarayanan

doi:10.1039/c9cc02021g

A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Naga Kiran Duggirala, Jinghan Li, N. S. Krishna Kumar, Gopinath Tata, Raj Suryanarayanan

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Abstract

A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and ¹⁵N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Original language	English (US)
Pages (from-to)	5551-5554
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	39
DOIs	https://doi.org/10.1039/c9cc02021g
State	Published - May 9 2019

Bibliographical note

Funding Information:
This research was partially supported by the William and Mildred Peters Endowment Fund. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the National Science Foundation-funded Materials Research Facilities Network. Solid-state NMR experiments were carried out at the Minnesota NMR Center, University of Minnesota. Anasuya Sahoo is acknowledged for her help.

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© 2019 The Royal Society of Chemistry.

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abstract = "A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.",

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AU - Tata, Gopinath

AU - Suryanarayanan, Raj

N1 - Funding Information: This research was partially supported by the William and Mildred Peters Endowment Fund. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the National Science Foundation-funded Materials Research Facilities Network. Solid-state NMR experiments were carried out at the Minnesota NMR Center, University of Minnesota. Anasuya Sahoo is acknowledged for her help. Publisher Copyright: © 2019 The Royal Society of Chemistry.

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A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Abstract

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