A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Naga Kiran Duggirala, Jinghan Li, N. S. Krishna Kumar, Gopinath Tata, Raj Suryanarayanan

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A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Original languageEnglish (US)
Pages (from-to)5551-5554
Number of pages4
JournalChemical Communications
Issue number39
StatePublished - Jan 1 2019


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  • Journal Article

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