A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Naga Kiran Duggirala, Jinghan Li, N. S. Krishna Kumar, Gopinath Tata, Raj Suryanarayanan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Original languageEnglish (US)
Pages (from-to)5551-5554
Number of pages4
JournalChemical Communications
Volume55
Issue number39
DOIs
StatePublished - Jan 1 2019

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Dispersions
carbopol 940
X ray crystallography
Polymers
Pharmaceutical Preparations
Differential scanning calorimetry
Infrared spectroscopy
Dissolution
Nuclear magnetic resonance
Nitrogen
Acids

PubMed: MeSH publication types

  • Journal Article

Cite this

A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. / Duggirala, Naga Kiran; Li, Jinghan; Krishna Kumar, N. S.; Tata, Gopinath; Suryanarayanan, Raj.

In: Chemical Communications, Vol. 55, No. 39, 01.01.2019, p. 5551-5554.

Research output: Contribution to journalArticle

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