A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

Naga Kiran Duggirala, Jinghan Li, N. S. Krishna Kumar, Gopinath Tata, Raj Suryanarayanan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Original languageEnglish (US)
Pages (from-to)5551-5554
Number of pages4
JournalChemical Communications
Volume55
Issue number39
DOIs
StatePublished - May 9 2019

Bibliographical note

Funding Information:
This research was partially supported by the William and Mildred Peters Endowment Fund. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the National Science Foundation-funded Materials Research Facilities Network. Solid-state NMR experiments were carried out at the Minnesota NMR Center, University of Minnesota. Anasuya Sahoo is acknowledged for her help.

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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