Commensal organisms appear to play significant roles in normal homeostasis as well as in the pathogenesis of HIV infection in a number of different organ systems. On November 17th and 18th, 2016, leading researchers from around the world met to discuss their insights on advances in our understanding of HIV and the microbiome at the National Institutes of Health (NIH) in Bethesda. Dr. Elhanan Borenstein of the University of Washington gave a keynote address where he discussed new developments in systems biology which hold the promise of illuminating the pathways by which these organisms interact with human physiology. He suggested that we need to get past correlations in microbiome research by using models and informatics which incorporate metagenomics to predict functional changes in the microbiome.
Bibliographical noteFunding Information:
1Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois. 2Department of Epidemiology and Biostatistics, The George Washington University, Washington, District of Columbia. 3Department of Virosciences, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands. 4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. 5Office of AIDS Research, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland. 6Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. 7Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California. 8Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. 9Institut de Recerca de la SIDA IrsiCaixa i Unitat VIH, Universitat Autònoma de Barcelona, Universitat de Vic, Catalonia, Spain. 10Department of Medicine, University of Colorado at Denver, Aurora, Colorado. 11Department of Medicine, Unit of Infectious Diseases, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. 12Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, Washington. 13Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 14Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois. *Both these authors contributed equally to this work.
- HIV transmission
- microbial translocation