A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in Syrian golden hamsters

Jörn Hilfrich, Stephen S. Hecht, Dietrich Hoffmann

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

N′-Nitrosonornicotine (NNN) and N′-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalCancer Letters
Volume2
Issue number3
DOIs
StatePublished - Jan 1977

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